QIP1 Antibody (B-6): sc-390535

QIP1 Antibody (B-6) is a mouse monoclonal IgG1 antibody that detects QIP1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). QIP1, also known as KPNA4, IPOA3, or SRP3, plays a crucial role in nuclear import by forming a complex with importin β, specifically karyopherin β1, which acts as its adapter protein. This interaction is vital for the transport of proteins containing nuclear localization signal motifs into the nucleus, a process essential for regulating gene expression and cellular function. The structure of QIP1 includes an IBB domain at its hydrophilic N-terminus, which is necessary for binding to karyopherin β1, along with ten ARM repeats in its hydrophobic central region that facilitate substrate recognition. QIP1 is predominantly expressed in tissues such as the pancreas, lung, ovary, testis, small intestine, heart, and skeletal muscle, where QIP1 exhibits both cytoplasmic and nuclear localization, underscoring its importance in cellular transport mechanisms. Anti-QIP1 antibody (B-6) is an invaluable tool for researchers studying nuclear transport pathways and their implications in various biological processes and diseases.

The preferred QIP1 antibody is QIP1 Antibody (3D10): sc-101547.