Pygopus 1 Antibody (3E1): sc-517079

Pygopus 1 Antibody (3E1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Pygopus 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Pygopus 1 antibody (3E1) is available as the non-conjugated format. Pygopus 1, also known as PYGO1, is a 419 amino acid protein that plays a crucial role in gene expression regulation within the nucleus, primarily through involvement in the Wnt signaling pathway. This pathway is essential for various developmental processes and cellular functions, including cell proliferation, differentiation, and migration. Pygopus 1 interacts with Bcl-9, a co-activator that enhances β-catenin transcriptional activity, thereby influencing target gene expression vital for embryonic development and tissue homeostasis. Pygopus 1 is encoded on human chromosome 15, a region significant for numerous gene encodings and association with various genetic disorders, including Angelman and Prader-Willi syndromes, which arise from deletions or mutations in this chromosomal region. Understanding Pygopus 1 function and interactions is important for elucidating developmental biology roles and potential disease mechanisms.

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Pygopus 1 Antibody (3E1) References:

1. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.  |  Kramps, T., et al. 2002. Cell. 109: 47-60. PMID: 11955446
2. A new nuclear component of the Wnt signalling pathway.  |  Thompson, B., et al. 2002. Nat Cell Biol. 4: 367-73. PMID: 11988739
3. Pygopus residues required for its binding to Legless are critical for transcription and development.  |  Townsley, FM., et al. 2004. J Biol Chem. 279: 5177-83. PMID: 14612447
4. Analysis of the DNA sequence and duplication history of human chromosome 15.  |  Zody, MC., et al. 2006. Nature. 440: 671-5. PMID: 16572171
5. Effective gene therapy in an authentic model of Tay-Sachs-related diseases.  |  Cachón-González, MB., et al. 2006. Proc Natl Acad Sci U S A. 103: 10373-10378. PMID: 16801539
6. Molecular epigenetics of Angelman syndrome.  |  Lalande, M. and Calciano, MA. 2007. Cell Mol Life Sci. 64: 947-60. PMID: 17347796
7. [The Prader-Willi syndrome].  |  Diene, G., et al. 2007. Ann Endocrinol (Paris). 68: 129-37. PMID: 17499572
8. Detailed analysis of 15q11-q14 sequence corrects errors and gaps in the public access sequence to fully reveal large segmental duplications at breakpoints for Prader-Willi, Angelman, and inv dup(15) syndromes.  |  Makoff, AJ. and Flomen, RH. 2007. Genome Biol. 8: R114. PMID: 17573966

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Pygopus 1 Antibody (3E1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Pygopus 1 Antibody (3E1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Pygopus 1 Antibody (3E1) Specifications

Alternate Product Name: Pygopus 1

Product Clone Name: 3E1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 101-200

Epitope Target: Pygopus 1

Epitope Species: human

Product Reactivity/Detection: Pygopus 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Pygopus 1 Antibody (3E1): N/A