PTPRCAP Antibody (17A5): sc-59290
- PTPRCAP Antibody (17A5) is a mouse monoclonal IgG1 PTPRCAP antibody provided at 500 µl supernatant
- raised against the cytoplasmic domain of LPAP of human origin
- recommended for detection of PTPRCAP of human origin by WB, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PTPRCAP Antibody (17A5). This work is in progress.
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PTPRCAP Antibody (17A5) is a mouse monoclonal IgG1 antibody that detects PTPRCAP protein of human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-PTPRCAP antibody (17A5) is available as the non-conjugated format. PTPRCAP protein, also known as protein tyrosine phosphatase, receptor type, C-associated protein, is a 206 amino acid single-pass membrane protein that plays a crucial role in the immune system by stabilizing the association of CD45, a vital regulator of T- and B-lymphocyte activation. This interaction is essential for modulating the threshold of T-cell activation, which is critical for an effective immune response. PTPRCAP is implicated in the activation of oncogenic Src family kinases, highlighting its importance in both normal immune function and potential pathological conditions. The regulation of protein tyrosine phosphorylation, which PTPRCAP is involved in, influences various cellular responses, including growth, differentiation, and survival, making PTPRCAP a significant target for research in immunology and cancer biology.
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PTPRCAP Antibody (17A5) References:
- Apoptosis mediated through CD45 is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein. | Fortin, M., et al. 2002. J Immunol. 168: 6084-9. PMID: 12055218
- The role of the PTPRC (CD45) mutation in the development of multiple sclerosis in the North West region of the United Kingdom. | Nicholas, RS., et al. 2003. J Neurol Neurosurg Psychiatry. 74: 944-5. PMID: 12810785
- CD45-associated protein inhibits CD45 dimerization and up-regulates its protein tyrosine phosphatase activity. | Takeda, A., et al. 2004. Blood. 103: 3440-7. PMID: 14715639
- PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients. | Cocco, E., et al. 2004. J Neurol. 251: 1085-8. PMID: 15372250
- Usefulness of CD45 density in the diagnosis of B-cell chronic lymphoproliferative disorders. | Maljaei, SH., et al. 2005. Indian J Med Sci. 59: 187-94. PMID: 15985726
- CD45-associated protein promotes the response of primary CD4 T cells to low-potency T-cell receptor (TCR) stimulation and facilitates CD45 association with CD3/TCR and lck. | Leitenberg, D., et al. 2007. Immunology. 121: 545-54. PMID: 17428310
- A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression. | Ju, H., et al. 2009. Neoplasia. 11: 1340-7. PMID: 20019842
- LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes. | Schraven, B., et al. 1994. J Biol Chem. 269: 29102-11. PMID: 7961877
- Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45. | Bruyns, E., et al. 1995. J Biol Chem. 270: 31372-6. PMID: 8537410
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTPRCAP Antibody (17A5) | sc-59290 | 500 µl supernatant | $322.00 |