PTPMT1 Antibody (B-3): sc-390901
- PTPMT1 Antibody (B-3) is a mouse monoclonal IgG2b κ PTPMT1 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 77-139 within an internal region of PTPMT1 of human origin
- PTPMT1 Antibody (B-3) is recommended for detection of PTPMT1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PTPMT1 Antibody (B-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for PTPMT1 Antibody (B-3) for WB and IHC(P) applications. This reagent is now offered in a bundle with PTPMT1 Antibody (B-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
QUICK LINKS
SEE ALSO...
PTPMT1 Antibody (B-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects PTPMT1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PTPMT1 (B-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PTPMT1, also known as protein tyrosine phosphatase mitochondrial 1, MOSP, or phosphoinositide lipid phosphatase, is a crucial enzyme that plays a significant role in mitochondrial function. PTPMT1 is predominantly localized to the matrix face of the inner mitochondrial membrane, where PTPMT1 is responsible for dephosphorylating key mitochondrial proteins. This activity is vital for the regulation of ATP production and insulin secretion, particularly in pancreatic β cells, where PTPMT1 is highly expressed. PTPMT1 exhibits a specific preference for the lipid signaling molecule phosphatidylinositol 5-phosphate (PI(5)P), highlighting PTPMT1′s importance in lipid metabolism and signaling pathways that influence cellular energy homeostasis. Anti-PTPMT1 antibody (B-3) enables researchers to gain insights into the regulatory mechanisms of mitochondrial function and their implications in metabolic diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PTPMT1 Antibody (B-3) References:
- A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. | Merlot, S., et al. 2003. J Biol Chem. 278: 39866-73. PMID: 12878591
- A PTEN-like phosphatase with a novel substrate specificity. | Pagliarini, DJ., et al. 2004. J Biol Chem. 279: 38590-6. PMID: 15247229
- Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. | Pagliarini, DJ., et al. 2005. Mol Cell. 19: 197-207. PMID: 16039589
- Firing up mitochondrial activities with PTPMT1. | Boisclair, Y. and Tremblay, ML. 2005. Mol Cell. 19: 291-2. PMID: 16061174
- Mitochondrial modulation: reversible phosphorylation takes center stage? | Pagliarini, DJ. and Dixon, JE. 2006. Trends Biochem Sci. 31: 26-34. PMID: 16337125
- Mitochondria: more than just a powerhouse. | McBride, HM., et al. 2006. Curr Biol. 16: R551-60. PMID: 16860735
- A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. | Lu, G., et al. 2007. Genes Dev. 21: 784-96. PMID: 17374715
- Phosphoinositide phosphatases in a network of signalling reactions. | Blero, D., et al. 2007. Pflugers Arch. 455: 31-44. PMID: 17605038
- Identification of the flavoprotein of succinate dehydrogenase and aconitase as in vitro mitochondrial substrates of Fgr tyrosine kinase. | Salvi, M., et al. 2007. FEBS Lett. 581: 5579-85. PMID: 17997986
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTPMT1 Antibody (B-3) | sc-390901 | 200 µg/ml | $316.00 | |||
PTPMT1 Antibody (B-3): m-IgGκ BP-HRP Bundle | sc-523725 | 200 µg Ab, 40 µg BP | $354.00 | |||
PTPMT1 Antibody (B-3) AC | sc-390901 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PTPMT1 Antibody (B-3) HRP | sc-390901 HRP | 200 µg/ml | $316.00 | |||
PTPMT1 Antibody (B-3) FITC | sc-390901 FITC | 200 µg/ml | $330.00 | |||
PTPMT1 Antibody (B-3) PE | sc-390901 PE | 200 µg/ml | $343.00 | |||
PTPMT1 Antibody (B-3) Alexa Fluor® 488 | sc-390901 AF488 | 200 µg/ml | $357.00 | |||
PTPMT1 Antibody (B-3) Alexa Fluor® 546 | sc-390901 AF546 | 200 µg/ml | $357.00 | |||
PTPMT1 Antibody (B-3) Alexa Fluor® 594 | sc-390901 AF594 | 200 µg/ml | $357.00 | |||
PTPMT1 Antibody (B-3) Alexa Fluor® 647 | sc-390901 AF647 | 200 µg/ml | $357.00 | |||
PTPMT1 Antibody (B-3) Alexa Fluor® 680 | sc-390901 AF680 | 200 µg/ml | $357.00 | |||
PTPMT1 Antibody (B-3) Alexa Fluor® 790 | sc-390901 AF790 | 200 µg/ml | $357.00 | |||
PTPMT1 (B-3) Neutralizing Peptide | sc-390901 P | 100 µg/0.5 ml | $68.00 |