Molecular structure of PTP Inhibitor V, PHPS1, CAS Number: 314291-83-3
PTP Inhibitor V, PHPS1 (CAS 314291-83-3)
See product citations (12)
Alternate Names:
PhenylHydrazonoPyrazolone Sulfonate 1
Application:
PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2
CAS Number:
314291-83-3
Purity:
≥95%
Molecular Weight:
465.45
Molecular Formula:
C21H15N5O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of SH-PTP2 (Shp-2) (IC50 and Ki = 2.1 and 0.73muM, respectively). PHPS1 inhibits PCPTP1 (ECPTP), PTP1B, SH-PTP1 (Shp1), mycobacterium MptpA only at higher concentrations (IC50 = 5.4, 19, 30, and 39 muM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 muM. PTP Inhibitor V, PHPS1 may act to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.
PTP Inhibitor V, PHPS1 (CAS 314291-83-3) References
- Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. | Hellmuth, K., et al. 2008. Proc Natl Acad Sci U S A. 105: 7275-80. PMID: 18480264
- Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis. | Tao, B., et al. 2014. J Immunol. 193: 2801-11. PMID: 25127857
- SHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1. | Li, S., et al. 2014. J Biol Chem. 289: 34152-60. PMID: 25331952
- Shp2 Deficiency Impairs the Inflammatory Response Against Haemophilus influenzae by Regulating Macrophage Polarization. | Zhao, L., et al. 2016. J Infect Dis. 214: 625-33. PMID: 27330052
- SH2 Domain-Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis. | Tzouvelekis, A., et al. 2017. Am J Respir Crit Care Med. 195: 500-514. PMID: 27736153
- Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice. | Xu, J., et al. 2017. J Immunol. 199: 2323-2332. PMID: 28814604
- Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the Inhibition of Topoisomerase II and Hsp90. | Lee, MG., et al. 2018. Mar Drugs. 16: PMID: 29890785
- Protein tyrosine phosphatase 11 acts through RhoA/ROCK to regulate eosinophil accumulation in the allergic airway. | Xu, C., et al. 2019. FASEB J. 33: 11706-11720. PMID: 31361966
- PTPN11 (SHP2) Is Indispensable for Growth Factors and Cytokine Signal Transduction During Bovine Oocyte Maturation and Blastocyst Development. | Idrees, M., et al. 2019. Cells. 8: PMID: 31635340
- SHP2 mutations induce precocious gliogenesis of Noonan syndrome-derived iPSCs during neural development in vitro. | Ju, Y., et al. 2020. Stem Cell Res Ther. 11: 209. PMID: 32493428
- SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model. | Jiang, J., et al. 2020. Mol Med. 26: 89. PMID: 32957908
- SHP2 Nuclear/Cytoplasmic Trafficking in Granulosa Cells Is Essential for Oocyte Meiotic Resumption and Maturation. | Idrees, M., et al. 2020. Front Cell Dev Biol. 8: 611503. PMID: 33553147
- Shp2 regulates PM2.5-induced airway epithelial barrier dysfunction by modulating ERK1/2 signaling pathway. | Zhang, Y., et al. 2021. Toxicol Lett. 350: 62-70. PMID: 34252507
- Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways. | Fu, NJ., et al. 2022. Toxicol Appl Pharmacol. 441: 115988. PMID: 35307375
- SHP-2-induced M2 polarization of tumor associated macrophages via IL-4 regulate colorectal cancer progression. | Li, Z., et al. 2023. Front Oncol. 13: 1027575. PMID: 36776333
Inhibitor of:
PCPTP1, PTP1B, SH-PTP1, and SH-PTP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTP Inhibitor V, PHPS1, 10 mg | sc-222226 | 10 mg | $243.00 |