PTH/PTHrP-R Antibody (3D1.1): sc-12722

PTH/PTHrP-R Antibody (3D1.1) is a mouse monoclonal IgG1 kappa light chain antibody that detects the PTH/PTHrP-R protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). PTH/PTHrP-R monoclonal antibody (3D1.1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The parathyroid hormone (PTH) receptor, also known as PTH/PTHrP-R, plays a crucial role in calcium homeostasis and bone metabolism by mediating the effects of PTH and parathyroid hormone-related peptide (PTHrP). PTH/PTHrP-R is primarily located on the surface of target cells in the bone and kidney, where PTH/PTHrP-R facilitates the actions of PTH and PTHrP, leading to increased calcium reabsorption in the kidneys and enhanced bone resorption. Proper functioning of PTH/PTHrP-R is vital for maintaining calcium levels in the bloodstream, and dysregulation of PTH/PTHrP-R can lead to conditions such as hyperparathyroidism or osteoporosis. The gene encoding PTH/PTHrP-R is located on human chromosome 3p21.31, and PTH/PTHrP-R expression is tightly regulated by calcium levels and other hormonal signals, underscoring PTH/PTHrP-R importance in endocrine signaling pathways.

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PTH/PTHrP-R Antibody (3D1.1) References:

1. Role of signal transduction in internalization of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein.  |  Huang, Z., et al. 1999. Endocrinology. 140: 1294-300. PMID: 10067856
2. Receptors for PTH and PTHrP: their biological importance and functional properties.  |  Mannstadt, M., et al. 1999. Am J Physiol. 277: F665-75. PMID: 10564229
3. Apoptosis mediated by activation of the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein (PTHrP).  |  Turner, PR., et al. 2000. Mol Endocrinol. 14: 241-54. PMID: 10674397
4. Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: association with serum-induced cell proliferation.  |  Watson, PH., et al. 2000. Bone. 26: 221-5. PMID: 10709993
5. Expression of PTHrP and PTHR (PTH/PTHrP-r) mRNAs and polypeptides in bovine ovary and stimulation of bovine blastocyst development in vitro following PTHrP treatment during oocyte maturation.  |  Watson, PH., et al. 2001. Anat Embryol (Berl). 203: 175-84. PMID: 11303903
6. Expressions of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP-receptor (PTH/PTHrP-R) in gastrointestinal stromal tumours (GISTs), leiomyomas and schwannomas.  |  Yoshizaki, A., et al. 2004. Scand J Gastroenterol. 39: 133-7. PMID: 15000274
7. Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long-Acting PTH.  |  Sato, T., et al. 2021. JBMR Plus. 5: e10441. PMID: 33977197
8. Lead optimization of pyrido[2,3-d][1]benzazepin-6-one derivatives leading to the discovery of a potent, selective, and orally available human parathyroid hormone receptor 1 (hPTHR1) antagonist (DS69910557).  |  Arai, Y., et al. 2022. Bioorg Med Chem. 64: 116763. PMID: 35487102
9. Expressions of parathyroid hormone-related protein (PTHrP) and parathyroid hormone receptor-1 (PTH1R) in the condylar cartilage of temporomandibular joint modulated by occlusal elevation.  |  Zhuang, Q., et al. 2023. J Dent Sci. 18: 626-635. PMID: 37021209
10. Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acid in human amnion and chorion-decidua: implications for secretion and function.  |  Bruns, ME., et al. 1995. Am J Obstet Gynecol. 173: 739-46. PMID: 7573236
11. Coexpression of parathyroid hormone-related protein and its receptor in breast carcinoma: a potential autocrine effector system.  |  Iezzoni, JC., et al. 1998. Mod Pathol. 11: 265-70. PMID: 9521473
12. Dual signaling and ligand selectivity of the human PTH/PTHrP receptor.  |  Takasu, H., et al. 1999. J Bone Miner Res. 14: 11-20. PMID: 9893061

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PTH/PTHrP-R Antibody (3D1.1) has 43 citations in a variety of scientific publications.

Primary antibodies like Anti-PTH/PTHrP-R Antibody (3D1.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PTH/PTHrP-R Antibody (3D1.1) Specifications

Alternate Product Name: PTH1R

Product Clone Name: 3D1.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 155-169

Epitope Target: PTH/PTHrP-R

Epitope Species: human

Product Reactivity/Detection: PTH/PTHrP-R type I

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 43 citations in various scientific publications

Available Conjugates/Forms for PTH/PTHrP-R Antibody (3D1.1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, TRITC: Rhodamine