PSMB11 Antibody (H-1): sc-515132
- PSMB11 Antibody (H-1) is a mouse monoclonal IgG1 κ PSMB11 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 113-130 within an internal region of PSMB11 of human origin
- PSMB11 Antibody (H-1) is recommended for detection of PSMB11 of human origin by WB, IP, IF and ELISA
- Anti-PSMB11 Antibody (H-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for PSMB11 Antibody (H-1) for WB applications. This reagent is now offered in a bundle with PSMB11 Antibody (H-1) (see ordering information below).
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PSMB11 Antibody (H-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects PSMB11 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PSMB11 (H-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSMB11, also known as Proteasome subunit beta type-11 or BETA5T, is a crucial component of the 26S proteasome, a multi-subunit protease complex responsible for the selective degradation of ubiquitinated proteins, which is vital for maintaining cellular homeostasis and regulating various cellular processes. The 26S proteasome consists of a 20S core particle that houses the proteolytic activity and two 19S regulatory particles that facilitate the recognition and unfolding of substrates. The 20S core is composed of 14 subunits arranged in a cylindrical structure, with the outer rings made up of seven alpha subunits and the inner rings containing seven beta subunits, where PSMB11 plays a significant role in the catalytic activity of the proteasome. PSMB11 is particularly important in CD8-positive T-cells, where PSMB11 helps modulate immune responses by reducing chymotrypsin-like activity, thereby influencing the degradation of specific proteins involved in immune signaling.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSMB11 Antibody (H-1) References:
- Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heart. | Razeghi, P., et al. 2006. Biochem Biophys Res Commun. 342: 361-4. PMID: 16483544
- Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein. | Kwak, MK., et al. 2007. Life Sci. 80: 2411-20. PMID: 17521679
- Regulation of CD8+ T cell development by thymus-specific proteasomes. | Murata, S., et al. 2007. Science. 316: 1349-53. PMID: 17540904
- Intermediates in the formation of mouse 20S proteasomes: implications for the assembly of precursor beta subunits. | Nandi, D., et al. 1997. EMBO J. 16: 5363-75. PMID: 9311996
- Genetic relationships of the genes encoding the human proteasome beta subunits and the proteasome PA28 complex. | McCusker, D., et al. 1997. Genomics. 45: 362-7. PMID: 9344661
- Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). | Orlowski, M., et al. 1997. Biochemistry. 36: 13946-53. PMID: 9374874
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSMB11 Antibody (H-1) | sc-515132 | 200 µg/ml | $316.00 | |||
PSMB11 Antibody (H-1): m-IgG1 BP-HRP Bundle | sc-531800 | 200 µg Ab; 20 µg BP | $354.00 | |||
PSMB11 Antibody (H-1) AC | sc-515132 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PSMB11 Antibody (H-1) HRP | sc-515132 HRP | 200 µg/ml | $316.00 | |||
PSMB11 Antibody (H-1) FITC | sc-515132 FITC | 200 µg/ml | $330.00 | |||
PSMB11 Antibody (H-1) PE | sc-515132 PE | 200 µg/ml | $343.00 | |||
PSMB11 Antibody (H-1) Alexa Fluor® 488 | sc-515132 AF488 | 200 µg/ml | $357.00 | |||
PSMB11 Antibody (H-1) Alexa Fluor® 546 | sc-515132 AF546 | 200 µg/ml | $357.00 | |||
PSMB11 Antibody (H-1) Alexa Fluor® 594 | sc-515132 AF594 | 200 µg/ml | $357.00 | |||
PSMB11 Antibody (H-1) Alexa Fluor® 647 | sc-515132 AF647 | 200 µg/ml | $357.00 | |||
PSMB11 Antibody (H-1) Alexa Fluor® 680 | sc-515132 AF680 | 200 µg/ml | $357.00 | |||
PSMB11 Antibody (H-1) Alexa Fluor® 790 | sc-515132 AF790 | 200 µg/ml | $357.00 | |||
PSMB11 (H-1) Neutralizing Peptide | sc-515132 P | 100 µg/0.5 ml | $68.00 |