PSG1 Antibody (BAP3): sc-59348

PSG1 Antibody (BAP3) is a mouse monoclonal IgG1 kappa light chain antibody that detects PSG1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). PSG1 (BAP3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Pregnancy-specific glycoprotein 1 (PSG1), also known as CD66f, is a crucial member of the PSG family, which consists of closely related secreted glycoproteins predominantly expressed in fetal placental syncytiotrophoblast cells. PSG proteins are characterized by a distinctive N-terminal domain that shares homology with the immunoglobulin variable region, which is significant for their role in immune modulation. PSG1 is detectable in maternal serum as early as two to three weeks into pregnancy, with levels increasing throughout gestation, ultimately becoming the most abundant fetal protein in maternal blood at term. PSG1 plays a vital role in stimulating the secretion of TH2-type cytokines from monocytes, which is essential for promoting a favorable immune environment during pregnancy, thereby protecting the semi-allotypic fetus from maternal immune rejection. Additionally, PSGs are implicated in trophoblast tumors, highlighting their importance in both normal and pathological conditions. With eleven human PSG proteins (PSG1-PSG11) identified, anti-PSG1 antibody (BAP3) serves as a valuable tool for researchers studying the complex interactions of these proteins in pregnancy and related disorders.

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PSG1 Antibody (BAP3) References:

1. Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6 and TGF-beta1 by human monocytes.  |  Snyder, SK., et al. 2001. Am J Reprod Immunol. 45: 205-16. PMID: 11327547
2. Binding of pregnancy-specific glycoprotein 17 to CD9 on macrophages induces secretion of IL-10, IL-6, PGE2, and TGF-beta1.  |  Ha, CT., et al. 2005. J Leukoc Biol. 77: 948-57. PMID: 15772125
3. Cloning and expression of genes encoding human pregnancy-specific glycoproteins.  |  Lei, KJ., et al. 1992. J Biol Chem. 267: 16371-8. PMID: 1644821
4. Human pregnancy-specific beta 1-glycoproteins are coded within chromosome 19.  |  Barnett, TR., et al. 1989. Am J Hum Genet. 44: 890-3. PMID: 2786334
5. Pregnancy-specific beta 1-glycoprotein: cDNA cloning, tissue expression, and species specificity of one member of the PS beta G family.  |  Niemann, SC., et al. 1989. Hum Genet. 82: 239-43. PMID: 2786492
6. Maternal levels of pregnancy-specific beta 1-glycoprotein (SP-1) are elevated in pregnancies affected by Down's syndrome.  |  Bartels, I. and Lindemann, A. 1988. Hum Genet. 80: 46-8. PMID: 2971018
7. Pregnancy-specific glycoprotein gene expression and the induction by 5-bromo-2'-deoxyuridine.  |  Pan, CJ., et al. 1994. Biochemistry. 33: 7260-6. PMID: 8003489
8. The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the carcinoembryonic antigen (CEA) family.  |  Teglund, S., et al. 1994. Genomics. 23: 669-84. PMID: 7851896

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PSG1 Antibody (BAP3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-PSG1 Antibody (BAP3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PSG1 Antibody (BAP3) Specifications

Alternate Product Name: PSG1

Product Clone Name: BAP3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CD66f

Epitope Species: human

Product Reactivity/Detection: PSG1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for PSG1 Antibody (BAP3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin