PSD-95 Antibody (7E3): sc-32290

PSD-95 Antibody (7E3) is a mouse monoclonal IgG1 kappa light chain antibody that detects PSD-95 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-PSD-95 antibody (7E3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSD-95, also known as SAP 90, plays a crucial role in organizing synaptic signaling complexes and is essential for proper functioning of excitatory synapses. PSD-95 is primarily located at postsynaptic density of neurons, where PSD-95 interacts with various receptors and scaffolding proteins, facilitating clustering of glutamate receptors and other signaling molecules. This localization is vital for synaptic plasticity, a process that underlies learning and memory. PSD-95 forms complexes with other proteins, such as NMDA and AMPA receptors, underscoring PSD-95′s importance in modulating synaptic strength and transmission. Additionally, PSD-95′s interaction with proteins like tumor suppressor APC suggests a role in regulating cellular growth and signaling pathways, highlighting significance beyond synaptic function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PSD-95 Antibody (7E3) References:

1. Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 A resolution.  |  Stehle, T. and Schulz, GE. 1992. J Mol Biol. 224: 1127-41. PMID: 1314905
2. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein.  |  Cho, KO., et al. 1992. Neuron. 9: 929-42. PMID: 1419001
3. Tumor-suppressor genes of Drosophila melanogaster.  |  Gateff, E. and Mechler, BM. 1989. Crit Rev Oncog. 1: 221-45. PMID: 2518684
4. PSD-95 protects synapses from β-amyloid.  |  Dore, K., et al. 2021. Cell Rep. 35: 109194. PMID: 34077732
5. O-GlcNAcylation modulates liquid-liquid phase separation of SynGAP/PSD-95.  |  Lv, P., et al. 2022. Nat Chem. 14: 831-840. PMID: 35637289
6. A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman syndrome.  |  Lau, KA., et al. 2023. Prog Neurobiol. 230: 102513. PMID: 37536482
7. Targeting postsynaptic glutamate receptor scaffolding proteins PSD-95 and PICK1 for obesity treatment.  |  Fadahunsi, N., et al. 2024. Sci Adv. 10: eadg2636. PMID: 38427737
8. Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein.  |  Müller, BM., et al. 1995. J Neurosci. 15: 2354-66. PMID: 7891172
9. Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.  |  Lue, RA., et al. 1994. Proc Natl Acad Sci U S A. 91: 9818-22. PMID: 7937897
10. ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctions.  |  Woods, DF. and Bryant, PJ. 1993. Mech Dev. 44: 85-9. PMID: 8155583
11. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.  |  Matsumine, A., et al. 1996. Science. 272: 1020-3. PMID: 8638125
12. Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein.  |  Makino, K., et al. 1997. Oncogene. 14: 2425-33. PMID: 9188857

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PSD-95 Antibody (7E3) has 106 citations in a variety of scientific publications.

Primary antibodies like Anti-PSD-95 Antibody (7E3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PSD-95 Antibody (7E3) Specifications

Alternate Product Name: PSD95

Product Clone Name: 7E3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: PSD-95

Epitope Species: rat

Product Reactivity/Detection: PSD-95

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 106 citations in various scientific publications

Available Conjugates/Forms for PSD-95 Antibody (7E3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin