PSD-95 Antibody (4E181): sc-71937

PSD-95 Antibody (4E181) is a mouse monoclonal IgG2a antibody that detects PSD-95 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). PSD-95, a member of the membrane-associated guanylate kinase (MAGUK) family, plays a crucial role in synaptic signaling and plasticity, which are essential for learning and memory processes. PSD-95 is primarily located at the postsynaptic density of excitatory synapses, where PSD-95 serves as a scaffolding protein that organizes and stabilizes various signaling complexes. Proper localization of PSD-95 is vital for maintaining synaptic integrity and facilitating communication between neurons. PSD-95 interacts with several key proteins, including NMDA and AMPA receptors, which are critical for synaptic transmission and plasticity. Dysregulation of PSD-95 and associated complexes has been implicated in various neurological disorders, highlighting PSD-95′s importance in both normal brain function and disease. With proven detection capabilities, anti-PSD-95 antibody (4E181) serves as an invaluable tool for researchers studying neuronal signaling pathways and their implications in health and disease.

The preferred PSD-95 antibody is PSD-95 Antibody (7E3): sc-32290.