PSD-95 Antibody (2Q129): sc-71936

PSD-95 Antibody (2Q129) is a mouse monoclonal IgG2a light chain antibody that detects PSD-95 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). PSD-95, a member of the membrane-associated guanylate kinase (MAGUK) family, plays a crucial role in synaptic signaling and plasticity by organizing and anchoring various proteins at the postsynaptic density of excitatory synapses. PSD-95 is primarily located at the postsynaptic membrane of neurons, where PSD-95 facilitates the clustering of neurotransmitter receptors and signaling molecules, thereby influencing synaptic strength and communication between neurons. Proper localization of PSD-95 is vital for maintaining synaptic integrity and function, as disruptions in PSD-95 expression or localization have been implicated in various neurodevelopmental and neuropsychiatric disorders. PSD-95 interacts with several key proteins, including NMDA and AMPA receptors, which are essential for synaptic transmission and plasticity. Anti-PSD-95 antibody (2Q129) enables researchers to gain insights into the dynamics of synaptic organization and the molecular mechanisms underlying synaptic function and dysfunction.

The preferred PSD-95 antibody is PSD-95 Antibody (7E3): sc-32290.