PRX II Antibody (H-4): sc-515429

PRX II Antibody (H-4) is a mouse monoclonal IgG2a antibody that detects peroxiredoxin II in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Peroxiredoxin II (PRX II) plays a crucial role in cellular defense against oxidative stress by reducing reactive oxygen species (ROS), thereby protecting cells from damage that can lead to various diseases, including cancer and neurodegenerative disorders. PRX II is primarily localized in the cytoplasm and is known to interact with thioredoxin, which serves as its electron donor during the antioxidation process. PRX II′s cytoplasmic localization enables rapid response to oxidative stress, allowing for efficient detoxification of ROS in the cellular environment. PRX II is overexpressed in certain cancers, such as breast cancer, indicating its potential role in tumorigenesis and progression. PRX II expression is also linked to the pathogenesis of Alzheimer′s disease and Down syndrome, highlighting its significance in both normal cellular function and disease states. With versatile applications and critical biological functions, anti-PRX II antibody (H-4) serves as an essential tool for researchers studying oxidative stress and its implications in health and disease.

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PRX II Antibody (H-4) References:

1. Inhibitory role of peroxiredoxin II (Prx II) on cellular senescence.  |  Han, YH., et al. 2005. FEBS Lett. 579: 4897-902. PMID: 16109412
2. Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NFkappaB pathway in mouse embryonic fibroblast (MEF) senescence.  |  Han, YH., et al. 2006. Free Radic Res. 40: 1182-9. PMID: 17050172
3. Protective and adaptogenic role of peroxiredoxin 2 (Prx2) in neutralization of oxidative stress induced by ionizing radiation.  |  Sharapov, MG., et al. 2019. Free Radic Biol Med. 134: 76-86. PMID: 30605715
4. Prx2 links ROS homeostasis to stemness of cancer stem cells.  |  Son, YW., et al. 2019. Free Radic Biol Med. 134: 260-267. PMID: 30611866
5. Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERBα/β pathway.  |  Ji, G., et al. 2019. Free Radic Biol Med. 145: 312-320. PMID: 31585206
6. Prx II reduces oxidative stress and cell senescence in chondrocytes by activating the p16-CDK4/6-pRb-E2F signaling pathway.  |  Shao, JH., et al. 2020. Eur Rev Med Pharmacol Sci. 24: 3448-3458. PMID: 32329817
7. Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice.  |  Zhang, XS., et al. 2021. Br J Pharmacol. 178: 1114-1132. PMID: 33326114
8. Reduced Expression of PRX2/ATPRX1, PRX8, PRX35, and PRX73 Affects Cell Elongation, Vegetative Growth, and Vasculature Structures in Arabidopsis thaliana.  |  Jeong, YJ., et al. 2022. Plants (Basel). 11: PMID: 36501391
9. Dihydromyricetin confers cerebroprotection against subarachnoid hemorrhage via the Nrf2-dependent Prx2 signaling cascade.  |  Li, XJ., et al. 2023. Phytomedicine. 119: 154997. PMID: 37523836
10. Exploring the role of Prx II in mitigating endoplasmic reticulum stress and mitochondrial dysfunction in neurodegeneration.  |  Jin, MH., et al. 2024. Cell Commun Signal. 22: 231. PMID: 38637880

The preferred PRX antibody is PRX Antibody (B-11): sc-137222.