PRX I Antibody (9D2): sc-59657
- PRX I Antibody (9D2) is a mouse monoclonal IgG1 κ PRX I antibody provided at 100 µg/ml
- raised against full length PRX I of human origin
- recommended for detection of PRX I of mouse, rat and human origin by IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PRX I Antibody (9D2). This work is in progress.
PRX I Antibody (9D2) is a mouse monoclonal IgG1 kappa light chain antibody that detects PRX I protein of mouse, rat, and human origin by immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PRX I antibody (9D2) is available as the non-conjugated form. The peroxiredoxin (PRX) family consists of six antioxidant proteins, including PRX I, which play a crucial role in cellular defense against reactive oxygen species (ROS) by catalyzing the reduction of peroxides. This function is vital for maintaining cellular homeostasis and preventing oxidative stress, which can lead to cellular damage and contribute to various diseases, including cancer and neurodegenerative disorders. PRX I is primarily localized in the cytoplasm, where PRX I interacts with thioredoxin to facilitate antioxidant activity, although PRX I can also be found in the nucleus and mitochondria under certain conditions. The human PRX I gene is expressed in multiple tissues, such as the liver, kidney, testis, lung, and nervous system, highlighting PRX I′s importance in various physiological processes. Notably, elevated levels of PRX I have been associated with breast cancer progression and are implicated in the pathogenesis of Alzheimer′s disease and Down syndrome, indicating PRX I′s potential as a biomarker for these conditions.
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PRX I Antibody (9D2) References:
- Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system. | Mizusawa, H., et al. 2000. Neurosci Lett. 283: 57-60. PMID: 10729633
- From cytoprotection to tumor suppression: the multifactorial role of peroxiredoxins. | Butterfield, LH., et al. 1999. Antioxid Redox Signal. 1: 385-402. PMID: 11233141
- Overexpression of peroxiredoxin in human breast cancer. | Noh, DY., et al. 2001. Anticancer Res. 21: 2085-90. PMID: 11497302
- Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome. | Kim, SH., et al. 2001. J Neural Transm Suppl. 223-35. PMID: 11771746
- Cell specific expression of peroxiredoxins in human lung and pulmonary sarcoidosis. | Kinnula, VL., et al. 2002. Thorax. 57: 157-64. PMID: 11828047
- Peroxiredoxins. | Hofmann, B., et al. 2002. Biol Chem. 383: 347-64. PMID: 12033427
- Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein. | Fujii, J. and Ikeda, Y. 2002. Redox Rep. 7: 123-30. PMID: 12189041
- Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. | Wang, X., et al. 2003. J Biol Chem. 278: 25179-90. PMID: 12732627
- Purification, characterization, and cloning of a heme-binding protein (23 kDa) in rat liver cytosol. | Iwahara, S., et al. 1995. Biochemistry. 34: 13398-406. PMID: 7577926
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRX I Antibody (9D2) | sc-59657 | 100 µg/ml | $316.00 |