PRX Antibody (A-6): sc-137150
- PRX Antibody (A-6) is a mouse monoclonal IgG2b κ, cited in 0 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 123-161 near the N-terminus of PRX II of human origin
- recommended for detection of PRX I, PRX II and PRX IV of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and porcine
- m-IgG2b BP-HRP is the preferred secondary detection reagent for PRX Antibody (A-6) for WB applications. This reagent is now offered in a bundle with PRX Antibody (A-6) (see ordering information below).
PRX Antibody (A-6) is a mouse monoclonal IgG2b antibody that detects peroxiredoxin (PRX) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PRX antibody (A-6) targets a crucial family of antioxidant proteins that play a significant role in cellular defense against reactive oxygen species (ROS), which can cause oxidative stress and damage to cellular components. PRX monoclonal antibody (A-6) recognizes peroxiredoxin proteins, including PRX I, II, III, IV, V, and VI, which utilize thioredoxin as an electron donor to mitigate oxidative damage, thereby maintaining cellular homeostasis and promoting cell survival. PRX III and V are localized in the mitochondria, where these proteins are essential for protecting mitochondrial integrity and function, while PRX I, II, IV, and VI are found in the cytoplasm, contributing to broader cellular antioxidant defense mechanisms. Expression of PRX proteins is particularly relevant in various pathological conditions; elevated levels of PRX I, II, and III have been associated with breast cancer progression, and upregulation in Alzheimer′s disease and Down syndrome suggests a potential role in the pathogenesis of these disorders. PRX (A-6) antibody′s versatility in detecting these proteins across different species and applications makes this reagent an invaluable tool for researchers studying oxidative stress, cancer biology, and neurodegenerative diseases.
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PRX Antibody (A-6) References:
- Protein-protein interactions within peroxiredoxin systems. | Noguera-Mazon, V., et al. 2006. Photosynth Res. 89: 277-90. PMID: 17089212
- The peroxiredoxin repair proteins. | Jönsson, TJ. and Lowther, WT. 2007. Subcell Biochem. 44: 115-41. PMID: 18084892
- A primer on peroxiredoxin biochemistry. | Karplus, PA. 2015. Free Radic Biol Med. 80: 183-90. PMID: 25452140
- Kinetic Approaches to Measuring Peroxiredoxin Reactivity. | Winterbourn, CC. and Peskin, AV. 2016. Mol Cells. 39: 26-30. PMID: 26813658
- Peroxiredoxin Involvement in the Initiation and Progression of Human Cancer. | Hampton, MB., et al. 2018. Antioxid Redox Signal. 28: 591-608. PMID: 29237274
- Autophagy Activated by Peroxiredoxin of Entamoeba histolytica. | Li, X., et al. 2020. Cells. 9: PMID: 33198056
- Peroxiredoxin, Senescence, and Cancer. | Wu, M., et al. 2022. Cells. 11: PMID: 35681467
- Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. | Xu, H., et al. 2023. Signal Transduct Target Ther. 8: 51. PMID: 36732502
- Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells. | Torres-Velarde, JM., et al. 2024. Free Radic Biol Med. 218: 82-93. PMID: 38579937
- A Physiological Approach to Explore How Thioredoxin-Glutathione Reductase (TGR) and Peroxiredoxin (Prx) Eliminate H2O2 in Cysticerci of Taenia. | Guevara-Flores, A., et al. 2024. Antioxidants (Basel). 13: PMID: 38671892
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRX Antibody (A-6) | sc-137150 | 200 µg/ml | $316.00 | |||
PRX Antibody (A-6): m-IgG2b BP-HRP Bundle | sc-548505 | 200 µg Ab; 10 µg BP | $354.00 | |||
PRX (A-6) Neutralizing Peptide | sc-137150 P | 100 µg/0.5 ml | $68.00 |