PRSS16 Antibody (D-7): sc-515700

PRSS16 Antibody (D-7) is a mouse monoclonal IgM antibody that detects PRSS16 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PRSS16 antibody (D-7) is available as the non-conjugated monoclonal isotype antibody. PRSS16, also known as serine protease 16 or thymus-specific serine protease (TSSP), consists of 514 amino acids and plays a crucial role in the alternative antigen presenting pathway, which is essential for T-cell positive selection. This process is vital for the development of a functional immune response, as T-cells can effectively recognize and respond to pathogens. PRSS16 is predominantly localized to lysosomal or endosomal cytoplasmic vesicles and is highly expressed in cortical thymic epithelial cells, where PRSS16 contributes to T-cell maturation. PRSS16 is encoded on human chromosome 6, within a large histone gene cluster near the major histocompatibility complex (MHC) class I region, highlighting PRSS16′s potential involvement in immune regulation. PRSS16 has been implicated in susceptibility to insulin-dependent diabetes mellitus (IDDM) and autoimmune conditions, making PRSS16 a significant target for research in immunology and disease mechanisms.

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PRSS16 Antibody (D-7) References:

1. Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus.  |  Bowlus, CL., et al. 1999. Cell Immunol. 196: 80-6. PMID: 10527559
2. Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases.  |  Lie, BA., et al. 2002. Genes Immun. 3: 306-12. PMID: 12140752
3. Expression, genomic structure and mapping of the thymus specific protease prss16: a candidate gene for insulin dependent diabetes mellitus susceptibility.  |  Cheunsuk, S., et al. 2002. J Autoimmun. 18: 311-6. PMID: 12144812
4. Alternatively spliced transcripts of the thymus-specific protease PRSS16 are differentially expressed in human thymus.  |  Luther, C., et al. 2005. Genes Immun. 6: 1-7. PMID: 15592422
5. Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease.  |  Lie, BA., et al. 2007. Hum Immunol. 68: 592-8. PMID: 17584581
6. Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex.  |  Viken, MK., et al. 2009. Genes Immun. 10: 323-33. PMID: 19295542
7. A transcription map of the major histocompatibility complex (MHC) class I region.  |  Gruen, JR., et al. 1996. Genomics. 36: 70-85. PMID: 8812418

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRSS16 Antibody (D-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PRSS16 Antibody (D-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRSS16 Antibody (D-7) Specifications

Alternate Product Name: PRSS16

Product Clone Name: D-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 365-382

Epitope Target: PRSS16

Epitope Species: human

Product Reactivity/Detection: PRSS16

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PRSS16 Antibody (D-7): N/A