PrP Antibody (H-8): sc-393165
- PrP Antibody (H-8) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-253 representing full length PrP of human origin
- recommended for detection of PrP of human origin by WB, IP, IF, IHC(P) and ELISA
- See PrP (5B2): sc-47730 for PrP antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2a BP-HRP is the preferred secondary detection reagent for PrP Antibody (H-8) for WB and IHC(P) applications. This reagent is now offered in a bundle with PrP Antibody (H-8) (see ordering information below).
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SEE ALSO...
PrP Antibody (H-8) is a mouse monoclonal IgG2a antibody that detects prion protein (PrP) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-PrP antibody (H-8) plays a crucial role in the study of prion diseases, which are lethal neurodegenerative disorders characterized by the misfolding of the prion protein. The normal cellular form of the prion protein, known as PrPc, is primarily located in the brain and is essential for various cellular functions, including synaptic transmission and neuroprotection. Proper localization of PrPc is vital, as disturbances in PrPc levels or distribution can lead to neurodegenerative conditions. In prion diseases, PrPc undergoes a conformational change to form the disease-associated isoform, PrPSc, which is resistant to proteolytic degradation and accumulates in the brain, leading to neuronal damage. PrP monoclonal antibody (H-8) differentiates between these two forms of the protein, making this tool essential for understanding the pathogenesis of prion diseases and developing potential therapeutic strategies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PrP Antibody (H-8) | sc-393165 | 200 µg/ml | $322.00 | |||
PrP Antibody (H-8): m-IgG2a BP-HRP Bundle | sc-546077 | 200 µg Ab; 10 µg BP | $361.00 |