PrP Antibody (G-12): sc-398451
- PrP Antibody (G-12) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 217-232 near the C-terminus of PrP of human origin
- Anti-PrP Antibody (G-12) is recommended for detection of PrP of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PrP Antibody (G-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PrP Antibody (G-12) for WB applications. These reagents are now offered in bundles with PrP Antibody (G-12) (see ordering information below).
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SEE ALSO...
PrP Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects prion protein (PrP) of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PrP antibody (G-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Prion protein plays a crucial role in neuroprotection and cellular signaling, and PrP misfolding is central to the pathogenesis of prion diseases, which are fatal neurodegenerative disorders. PrPc is predominantly located in the brain, where PrPc is involved in synaptic function and neuroprotection. When PrPc undergoes conformational changes to form PrPSc, PrPSc becomes resistant to proteolytic degradation, leading to toxic aggregate accumulation that disrupts cellular function and triggers neurodegeneration. PrPSc presence in affected individuals′ brains is a hallmark of transmissible spongiform encephalopathies, such as scrapie in sheep, bovine spongiform encephalopathy in cattle, and Creutzfeldt-Jakob disease in humans, highlighting anti-PrP antibody (G-12) significance in research and diagnostic applications related to these devastating conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PrP Antibody (G-12) | sc-398451 | 200 µg/ml | $322.00 | |||
PrP Antibody (G-12): m-IgG Fc BP-HRP Bundle | sc-527777 | 200 µg Ab; 10 µg BP | $361.00 | |||
PrP Antibody (G-12): m-IgG1 BP-HRP Bundle | sc-533150 | 200 µg Ab; 20 µg BP | $361.00 | |||
PrP Antibody (G-12) AC | sc-398451 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PrP Antibody (G-12) HRP | sc-398451 HRP | 200 µg/ml | $322.00 | |||
PrP Antibody (G-12) FITC | sc-398451 FITC | 200 µg/ml | $336.00 | |||
PrP Antibody (G-12) PE | sc-398451 PE | 200 µg/ml | $349.00 | |||
PrP Antibody (G-12) Alexa Fluor® 488 | sc-398451 AF488 | 200 µg/ml | $364.00 | |||
PrP Antibody (G-12) Alexa Fluor® 546 | sc-398451 AF546 | 200 µg/ml | $364.00 | |||
PrP Antibody (G-12) Alexa Fluor® 594 | sc-398451 AF594 | 200 µg/ml | $364.00 | |||
PrP Antibody (G-12) Alexa Fluor® 647 | sc-398451 AF647 | 200 µg/ml | $364.00 | |||
PrP Antibody (G-12) Alexa Fluor® 680 | sc-398451 AF680 | 200 µg/ml | $364.00 | |||
PrP Antibody (G-12) Alexa Fluor® 790 | sc-398451 AF790 | 200 µg/ml | $364.00 | |||
PrP (G-12) Neutralizing Peptide | sc-398451 P | 100 µg/0.5 ml | $69.00 |