PrP Antibody (AH6): sc-69896
- PrP Antibody (AH6) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 200 µg/ml
- raised against recombinant full length PrP of ovine origin
- recommended for detection of C-terminal amino acid residues 90-230 of PrP of mouse, rat, human, ovine, hamster and deer origin by WB, IP, FCM and ELISA
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See PrP (5B2): sc-47730 for PrP antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2a BP-HRP is the preferred secondary detection reagent for PrP Antibody (AH6) for WB applications. This reagent is now offered in a bundle with PrP Antibody (AH6) (see ordering information below).
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PrP Antibody (AH6) is a mouse monoclonal IgG2a antibody that detects prion protein (PrP) across multiple species including mouse, rat, human, ovine, hamster, and deer, by applications such as western blotting (WB), immunoprecipitation (IP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-PrP antibody (AH6) plays a crucial role in the study of prion diseases, which are lethal neurodegenerative disorders characterized by the misfolding of the prion protein. The normal cellular form of PrP, known as PrPc, is primarily located in the brain and is essential for various cellular functions, including synaptic transmission and neuroprotection. PrPc′s proper functioning is vital, as disruptions can lead to conversion into the pathogenic form, PrPSc, which is associated with the development of transmissible spongiform encephalopathies. PrPSc′s ability to resist proteolytic degradation and accumulate in the brain underscores the importance of monitoring PrP levels in research and clinical settings, as this monitoring provides insights into the mechanisms of prion diseases and potential therapeutic targets. PrP (AH6) monoclonal antibody is an invaluable tool for researchers investigating the pathogenesis of these disorders and the underlying biology of prion proteins.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PrP Antibody (AH6) References:
- Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation. | Gilch, S., et al. 2007. Vet Microbiol. 123: 377-86. PMID: 17493775
- Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. | Herrmann, US., et al. 2015. PLoS Pathog. 11: e1004662. PMID: 25710374
- Experimental Models of Inherited PrP Prion Diseases. | Watts, JC. and Prusiner, SB. 2017. Cold Spring Harb Perspect Med. 7: PMID: 28096244
- Toward the Atomic Structure of PrPSc. | Rodriguez, JA., et al. 2017. Cold Spring Harb Perspect Biol. 9: PMID: 28096267
- Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression. | Heisler, FF., et al. 2018. Neuron. 99: 1155-1169.e9. PMID: 30174115
- A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity. | Bardelli, M., et al. 2018. PLoS Pathog. 14: e1007335. PMID: 30273408
- PrP C as a Transducer of Physiological and Pathological Signals. | Panes, JD., et al. 2021. Front Mol Neurosci. 14: 762918. PMID: 34880726
- Cardiolipin externalization mediates prion protein (PrP) peptide 106-126-associated mitophagy and mitochondrial dysfunction. | Yang, D., et al. 2023. Front Mol Neurosci. 16: 1163981. PMID: 37333615
- Genetic modulation of CWD prion propagation in cervid PrP Drosophila. | Thackray, AM., et al. 2023. Biochem J. 480: 1485-1501. PMID: 37747806
- PrP meets alpha-synuclein: Molecular mechanisms and implications for disease. | Vieira, TCRG., et al. 2024. J Neurochem. 168: 1625-1639. PMID: 37855859
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PrP Antibody (AH6) | sc-69896 | 200 µg/ml | $322.00 | |||
PrP Antibody (AH6): m-IgG2a BP-HRP Bundle | sc-546003 | 200 µg Ab; 10 µg BP | $361.00 | |||
PrP Antibody (AH6) FITC | sc-69896 FITC | 200 µg/ml | $336.00 | |||
PrP Antibody (AH6) PE | sc-69896 PE | 200 µg/ml | $349.00 |