PrP Antibody (6G3): sc-52969
- PrP Antibody (6G3) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 130-150 of PrP of human origin
- recommended for detection of PrP of mouse, rat, human, bovine, ovine and deer origin by WB and IP
- See PrP (5B2): sc-47730 for PrP antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PrP Antibody (6G3). This work is in progress.
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SEE ALSO...
PrP Antibody (6G3) is a mouse monoclonal IgG1 antibody that detects prion protein (PrP) of mouse, rat, human, bovine, ovine, and deer by western blotting (WB) and immunoprecipitation (IP). Anti-PrP antibody (6G3) plays a crucial role in the study of prion diseases, which are lethal neurodegenerative disorders characterized by the misfolding of the prion protein. The normal cellular form of the prion protein, known as PrPc, is primarily located in the brain and is essential for various cellular functions, including synaptic transmission and neuroprotection. Understanding the localization of PrPc is vital, as PrPc presence in the brain is linked to maintaining neuronal health, while conversion to the disease-associated form, PrPSc, leads to neurodegeneration. The transition from PrPc to PrPSc involves a conformational change that renders PrPSc resistant to proteolytic degradation, which is a hallmark of prion diseases such as Creutzfeldt-Jakob disease in humans and scrapie in sheep. PrP monoclonal antibody (6G3) enables researchers to effectively investigate the dynamics of prion protein expression and implications in the pathogenesis of these devastating diseases, thereby contributing to the understanding of neurodegenerative mechanisms and potential therapeutic strategies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PrP Antibody (6G3) | sc-52969 | 50 µg/0.5 ml | $322.00 |