Anti-PROX1 Antibody (FM-79): sc-81983

PROX1 Antibody (FM-79) is a high quality monoclonal PROX1 antibody (also designated PROX1 antibody) suitable for the detection of the PROX1 protein of mouse, rat and human origin. PROX1 Antibody (FM-79) is available as the non-conjugated anti-PROX1 antibody. Homeodomain proteins are key regulators in the growth and development of tissues undergoing morphogenesis. PROX1 (homeobox prospero-like protein) is a 737 amino acid transcription factor necessary for progenitor-cell proliferation and cell-fate determination in embryonic tissue. PROX1 is actively expressed in the developing lens and can be detected in embryonic brain, kidney, liver and lung. During maturation, predominant expression is found in heart and liver rather than brain and kidney. The expression pattern of the PROX1 suggests that PROX1 has a role in determining cell fate in a variety of embryonic tissues. PROX1 contains a prospero-type homeobox DNA-binding domain, which conveys PROX1 function as a transcription factor. Decreased PROX1 expression due to hypermethylation suggests that PROX1 may also act as a tumor suppressor.