Proliferation Marker Antibody (JC1): sc-53424

Proliferation Marker Antibody (JC1) is a mouse monoclonal IgG2a kappa light chain antibody that detects the Proliferation Marker protein of human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Proliferation Marker (JC1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Proliferin, also known as mitogen-regulated protein 1, is a crucial secreted protein that plays a significant role in embryonic development by providing essential growth signals to target cells in both fetal and maternal tissues during mid-gestation. This protein is part of the somatotropin/prolactin growth hormone family, which is vital for regulating growth and development processes. Understanding proliferin function is important, as proliferin not only influences cell proliferation but also has implications in various physiological and pathological conditions, including cancer and reproductive health. Anti-Proliferation Marker antibody (JC1) accurately detects proliferin, making this reagent an invaluable tool for researchers studying developmental biology and related fields.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Proliferation Marker Antibody (JC1) References:

1. The Ki-67 protein: from the known and the unknown.  |  Scholzen, T. and Gerdes, J. 2000. J Cell Physiol. 182: 311-22. PMID: 10653597
2. Osteoblasts respond to hydroxyapatite surfaces with immediate changes in gene expression.  |  Xie, J., et al. 2004. J Biomed Mater Res A. 71: 108-17. PMID: 15368260
3. Negative glucocorticoid receptor response elements and their role in glucocorticoid action.  |  Dostert, A. and Heinzel, T. 2004. Curr Pharm Des. 10: 2807-16. PMID: 15379669
4. Cost containment in Oregon: as simple as A x B?  |  Goris, ML. 1992. JAMA. 267: 1780. PMID: 1545463
5. Adsorption of serum fetuin to hydroxylapatite does not contribute to osteoblast phenotype modifications.  |  Xie, J., et al. 2005. J Biomed Mater Res A. 73: 39-47. PMID: 15714505
6. Mitogen-regulated protein/proliferin mRNA induction following single applications of tumor promoters to murine skin.  |  Parfett, CL. 2005. Mol Carcinog. 43: 117-29. PMID: 15920718
7. Comparative aspects of the proliferation marker thymidine kinase 1 in human and canine tumour diseases.  |  von Euler, H. and Eriksson, S. 2011. Vet Comp Oncol. 9: 1-15. PMID: 21303450
8. Applications of PET imaging with the proliferation marker [18F]-FLT.  |  Peck, M., et al. 2015. Q J Nucl Med Mol Imaging. 59: 95-104. PMID: 25737423
9. Ki-67: more than a proliferation marker.  |  Sun, X. and Kaufman, PD. 2018. Chromosoma. 127: 175-186. PMID: 29322240
10. Transcriptional regulation of proliferin gene expression in response to serum in transfected mouse cells.  |  Linzer, DI. and Mordacq, JC. 1987. EMBO J. 6: 2281-8. PMID: 3478191
11. The Role of Ki67 in Evaluating Neoadjuvant Endocrine Therapy of Hormone Receptor-Positive Breast Cancer.  |  Zhang, A., et al. 2021. Front Endocrinol (Lausanne). 12: 687244. PMID: 34803903
12. Nucleotide sequence of a growth-related mRNA encoding a member of the prolactin-growth hormone family.  |  Linzer, DI. and Nathans, D. 1984. Proc Natl Acad Sci U S A. 81: 4255-9. PMID: 6087314

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Proliferation Marker Antibody (JC1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Proliferation Marker Antibody (JC1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Proliferation Marker Antibody (JC1) Specifications

Alternate Product Name: Proliferation Marker

Product Clone Name: JC1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Proliferation Marker

Epitope Species: human

Product Reactivity/Detection: Proliferation Marker

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Proliferation Marker Antibody (JC1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin