Progesterone Antibody (HPRO-2): sc-52167

Progesterone Antibody (HPRO-2) is a mouse monoclonal IgG2b light chain antibody that detects Progesterone in mammalian species through enzyme-linked immunosorbent assay (ELISA). Progesterone plays a crucial role in regulating the female menstrual cycle, supporting pregnancy, and facilitating embryogenesis, making Progesterone essential for reproductive health. The Progesterone receptor, a membrane-bound member of the steroid receptor superfamily, mediates the physiological effects of Progesterone. The Progesterone receptor gene (PGR) produces two nearly identical isoforms, PRA and PRB, through distinct promoters and translational start sites. PRA and PRB function as unique transcription factors, each activating specific response genes and physiological effects with minimal overlap. The Progesterone receptor structure includes a modulating N-terminal domain, a DNA binding domain, and a C-terminal steroid binding domain, which are vital for Progesterone interaction and subsequent gene regulation. Understanding Progesterone receptor structure provides insights into how hormonal signaling influences various biological processes, including cell growth, differentiation, and reproductive functions. Progesterone (HPRO-2) antibody serves as an invaluable tool for researchers studying these critical pathways in mammalian systems.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Progesterone Antibody (HPRO-2) References:

1. Progesterone and the progesterone receptor.  |  Bouchard, P. 1999. J Reprod Med. 44: 153-7. PMID: 11392025
2. The involvement of progesterone in the onset of human labour.  |  Astle, S., et al. 2003. Eur J Obstet Gynecol Reprod Biol. 108: 177-81. PMID: 12781407
3. Progesterone-mediated immunomodulation in pregnancy: its relevance to leukocyte immunotherapy of recurrent miscarriage.  |  Szekeres-Bartho, J. 2009. Immunotherapy. 1: 873-82. PMID: 20636029
4. The role of progesterone in implantation and trophoblast invasion.  |  Halasz, M. and Szekeres-Bartho, J. 2013. J Reprod Immunol. 97: 43-50. PMID: 23432871
5. Nonclassical progesterone signalling molecules in the nervous system.  |  Petersen, SL., et al. 2013. J Neuroendocrinol. 25: 991-1001. PMID: 23763432
6. Progesterone and allopregnanolone in the central nervous system: response to injury and implication for neuroprotection.  |  Guennoun, R., et al. 2015. J Steroid Biochem Mol Biol. 146: 48-61. PMID: 25196185
7. Progesterone resistance in endometriosis: origins, consequences and interventions.  |  Patel, BG., et al. 2017. Acta Obstet Gynecol Scand. 96: 623-632. PMID: 28423456
8. Epigenetic regulation of progesterone receptors and the onset of labour.  |  Ilicic, M., et al. 2019. Reprod Fertil Dev. 31: 1035-1048. PMID: 30944064
9. The role of progesterone and the progesterone receptor in cancer: progress in the last 5 years.  |  Check, JH. and Check, DL. 2023. Expert Rev Endocrinol Metab. 18: 5-18. PMID: 36647582
10. Progesterone action in mammalian uterus.  |  Jänne, OA. 1981. Acta Obstet Gynecol Scand Suppl. 101: 11-6. PMID: 7029999

The preferred Progesterone antibody is Progesterone Antibody (11P14): sc-53423.