Molecular structure of PRL-3 Inhibitor, CAS Number: 893449-38-2
PRL-3 Inhibitor (CAS 893449-38-2)
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Alternate Names:
1-(2-Bromobenzyloxy)-4-bromo-2-benzylidene rhodanine
Application:
PRL-3 Inhibitor is a cell permeable benzylidene rhodanine compound
CAS Number:
893449-38-2
Purity:
≥98%
Molecular Weight:
485.21
Molecular Formula:
C17H11Br2NO2S2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable benzylidene rhodanine compound that potently inhibits hPRL-3, a member of the regenerating liver family tyrosine phosphatases. Shown to reduce the invasiveness of murine melanoma B16F10 cells.
PRL-3 Inhibitor (CAS 893449-38-2) References
- Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors. | Ahn, JH., et al. 2006. Bioorg Med Chem Lett. 16: 2996-9. PMID: 16530413
- Down-modulation of keratin 8 phosphorylation levels by PRL-3 contributes to colorectal carcinoma progression. | Mizuuchi, E., et al. 2009. Int J Cancer. 124: 1802-10. PMID: 19115206
- Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma. | Ooki, A., et al. 2010. Int J Cancer. 127: 543-54. PMID: 19960436
- Requirement of phosphatase of regenerating liver-3 for the nucleolar localization of nucleolin during the progression of colorectal carcinoma. | Semba, S., et al. 2010. Cancer Sci. 101: 2254-61. PMID: 20860603
- Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer. | Ooki, A., et al. 2011. BMC Cancer. 11: 122. PMID: 21466710
- Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity. | Han, YM., et al. 2012. Bioorg Med Chem Lett. 22: 323-6. PMID: 22137788
- Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells. | Min, G., et al. 2013. Bioorg Med Chem Lett. 23: 3769-74. PMID: 23726031
- PRL-3 promotes migration and invasion and is associated with poor prognosis in salivary adenoid cystic carcinoma. | Dong, Q., et al. 2016. J Oral Pathol Med. 45: 111-8. PMID: 26041460
- Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3. | Abdollahi, P., et al. 2017. Mol Cancer Res. 15: 69-77. PMID: 27698077
- The combination of PRL-3 inhibitor with sorafenib synergistically promotes AML apoptosis. | Chen, X., et al. 2021. Neoplasma. 68: 832-841. PMID: 34348467
Inhibitor of:
PRL-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRL-3 Inhibitor, 10 mg | sc-222189 | 10 mg | $280.00 |