PRL-3 Inhibitor CAS: 893449-38-2
MF: C17H11Br2NO2S2
MW: 485.21
A cell permeable benzylidene rhodanine compound.

PRL-3 Inhibitor (CAS 893449-38-2)

PRL-3 Inhibitor | CAS 893449-38-2 is rated 5.0 out of 5 by 1.
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Alternate Names: 1-(2-Bromobenzyloxy)-4-bromo-2-benzylidene rhodanine
Application: PRL-3 Inhibitor is a cell permeable benzylidene rhodanine compound
CAS Number: 893449-38-2
Purity: ≥98%
Molecular Weight: 485.21
Molecular Formula: C17H11Br2NO2S2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PRL-3 Inhibitor is a cell-permeable benzylidene rhodanine compound that potently inhibits PRL-3 (hPRL-3), a member of the regenerating liver family tyrosine phosphatases. PRL-3 Inhibitor has been shown to reduce the invasiveness of murine melanoma B16F10 cells.


References

1. Ahn, J.H., et al. 2006. Bioorg. Med. Chem. Lett. 16: 2996-2999. PMID: 16530413

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml). Slight warming may be necessary for complete solubilization.
Storage :
Store at -20° C
Melting Point :
268.90° C (Predicted)
Boiling Point :
620.54° C (Predicted)
Density :
1.86 g/cm3 (Predicted)
Refractive Index :
n20D 1.77 (Predicted)
IC50 :
hPRL-3 : IC50 = 900 nM
pK Values :
pKa: 7.11 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
SMILES :
C1=CC=C(C(=C1)COC2=C(C=C(C=C2)Br)/C=C\\3/C(=O)NC(=S)S3)Br

Download SDS (MSDS)

Certificate of Analysis

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PRL-3 Inhibitor (CAS 893449-38-2)  Product Citations

See how others have used PRL-3 Inhibitor (CAS 893449-38-2). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26041460  Dong, Q. et al. 2016. J. Oral Pathol. Med. 45: 111-8.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Ahn Ahn, JH. et al. (PubMed 16530413) investigated the ability of several of rhodanine derivatives to inhibit PRL-3. They found that 1-(2-Bromobenzyloxy)-4-bromo-2-benzylidene rhodanine showed a significant ability to inhibit PRL-3. -SCBT Publication Review
Date published: 2015-04-08
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