PRL-3 Antibody (318): sc-130355

PRL-3 Antibody (318) is a mouse monoclonal IgG1 kappa light chain antibody that detects PRL-3 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-PRL-3 antibody (318) is available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. PRL-3, also known as Protein Tyrosine Phosphatase Type IVA, member 3 (PTP4A3), plays a crucial role in cellular signaling and is primarily expressed in heart and skeletal muscle, as well as in the epithelial cells of the small intestine, where PRL-3 associates with the cell plasma membrane. PRL-3 localization allows for the regulation of key signaling pathways that influence cell growth and differentiation. Notably, PRL-3 overexpression has been linked to the inhibition of angiotensin-II induced calcium mobilization, which is vital for various cellular functions, and PRL-3 has been implicated in promoting colorectal cancer metastasis, making PRL-3 a potential therapeutic target for cancer treatment.

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PRL-3 Antibody (318) References:

1. Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome.  |  Zeng, Q., et al. 2000. J Biol Chem. 275: 21444-52. PMID: 10747914
2. Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling.  |  Matter, WF., et al. 2001. Biochem Biophys Res Commun. 283: 1061-8. PMID: 11355880
3. PRL-3 and PRL-1 promote cell migration, invasion, and metastasis.  |  Zeng, Q., et al. 2003. Cancer Res. 63: 2716-22. PMID: 12782572
4. Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms.  |  Jeong, DG., et al. 2005. J Mol Biol. 345: 401-13. PMID: 15571731
5. PRL-3 promotes gastric cancer migration and invasion through a NF-κB-HIF-1α-miR-210 axis.  |  Zhang, C., et al. 2016. J Mol Med (Berl). 94: 401-15. PMID: 26548949
6. The phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells.  |  Slørdahl, TS., et al. 2016. Oncotarget. 7: 27295-306. PMID: 27036022
7. PRL-3 improves colorectal cancer cell proliferation and invasion through IL-8 mediated glycolysis metabolism.  |  Xu, H., et al. 2017. Int J Oncol. 51: 1271-1279. PMID: 28791350
8. The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition.  |  Rubio, T., et al. 2021. J Mol Med (Berl). 99: 1413-1426. PMID: 34129057
9. The phosphatase of regenerating liver-3 protein (PRL-3) promotes glioma cell invasiveness by interacting with β3 -tubulin.  |  Ge, Z., et al. 2022. Bioengineered. 13: 4112-4121. PMID: 35098869
10. PRL-3 and MMP9 Expression and Epithelial-Mesenchymal Transition Markers in Circulating Tumor Cells From Patients With Colorectal Cancer: Potential Value in Clinical Practice.  |  Hong, XC., et al. 2022. Front Oncol. 12: 878639. PMID: 35574414
11. Studies on nickel metabolism: interaction with other mineral elements.  |  Ling, JR. and Leach, RM. 1979. Poult Sci. 58: 591-6. PMID: 514946
12. Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1.  |  Zeng, Q., et al. 1998. Biochem Biophys Res Commun. 244: 421-7. PMID: 9514946

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRL-3 Antibody (318) has 25 citations in a variety of scientific publications.

Primary antibodies like Anti-PRL-3 Antibody (318) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRL-3 Antibody (318) Specifications

Alternate Product Name: PRL-3

Product Clone Name: 318

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: PRL-3

Epitope Species: mouse

Product Reactivity/Detection: PRL-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 25 citations in various scientific publications

Available Conjugates/Forms for PRL-3 Antibody (318): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin