PRL-3 Antibody (111AT714): sc-130245

PRL-3 Antibody (111AT714) is a mouse monoclonal IgG1 antibody that detects PRL-3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PRL-3 antibody (111AT714) is available in a non-conjugated form, allowing for versatile experimental use. PRL-3, also known as Protein Tyrosine Phosphatase Type IVA, member 3 (PTP4A3), plays a critical role in cellular signaling pathways, particularly in cancer progression. PRL-3 is primarily localized to the cell plasma membrane and is expressed in various tissues, including heart, skeletal muscle, and epithelial cells of the small intestine. PRL-3′s membrane association facilitates interactions with other signaling molecules, thereby influencing processes such as cell growth and migration. Notably, overexpression of PRL-3 has been linked to enhanced cell proliferation and metastasis in colorectal cancer, making PRL-3 a potential therapeutic target for intervention in cancer treatment. PRL-3′s ability to inhibit angiotensin-II induced calcium mobilization further underscores PRL-3′s importance in regulating cellular responses. With diverse applications and critical role in cancer biology, PRL-3 monoclonal antibody (111AT714) serves as an essential tool for researchers investigating the mechanisms of tumorigenesis and metastasis.

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PRL-3 Antibody (111AT714) References:

1. PRL-3 phosphatase and cancer metastasis.  |  Al-Aidaroos, AQ. and Zeng, Q. 2010. J Cell Biochem. 111: 1087-98. PMID: 21053359
2. PRL-3, an emerging marker of carcinogenesis, is strongly associated with poor prognosis.  |  Guzińska-Ustymowicz, K. and Pryczynicz, A. 2011. Anticancer Agents Med Chem. 11: 99-108. PMID: 21291404
3. PRL-3 activates mTORC1 in Cancer Progression.  |  Ye, Z., et al. 2015. Sci Rep. 5: 17046. PMID: 26597054
4. Regulatory mechanisms of phosphatase of regenerating liver (PRL)-3.  |  Rubio, T. and Köhn, M. 2016. Biochem Soc Trans. 44: 1305-1312. PMID: 27911713
5. PRL-3 promotes telomere deprotection and chromosomal instability.  |  Lian, S., et al. 2017. Nucleic Acids Res. 45: 6546-6571. PMID: 28482095
6. PRL-3 promotes breast cancer progression by downregulating p14ARF-mediated p53 expression.  |  Xie, H. and Wang, H. 2018. Oncol Lett. 15: 2795-2800. PMID: 29435006
7. The Phosphatase PRL-3 Is Involved in Key Steps of Cancer Metastasis.  |  Duciel, L., et al. 2019. J Mol Biol. 431: 3056-3067. PMID: 31207239
8. PRL-3 facilitates Hepatocellular Carcinoma progression by co-amplifying with and activating FAK.  |  Zhou, Q., et al. 2020. Theranostics. 10: 10345-10359. PMID: 32929353
9. PRL-3 induces a positive signaling circuit between glycolysis and activation of STAT1/2.  |  Vandsemb, EN., et al. 2021. FEBS J. 288: 6700-6715. PMID: 34092011
10. PRL-3 dephosphorylates p38 MAPK to promote cell survival under stress.  |  Shi, Y., et al. 2021. Free Radic Biol Med. 177: 72-87. PMID: 34662712

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PRL-3 Antibody (111AT714) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PRL-3 Antibody (111AT714) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PRL-3 Antibody (111AT714) Specifications

Alternate Product Name: PRL-3

Product Clone Name: 111AT714

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: PRL-3

Epitope Species: human

Product Reactivity/Detection: PRL-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PRL-3 Antibody (111AT714): N/A

The preferred PRL-3 antibody is PRL-3 Antibody (318): sc-130355.