PRIP Antibody (39-Q): sc-101129

PRIP Antibody (39-Q) is a mouse monoclonal IgG2a antibody that detects peroxisome proliferator-activated receptor-interacting protein (PRIP) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRIP is a crucial nuclear receptor co-activator that plays a significant role in regulating gene expression by binding to nuclear receptors and enhancing their transcriptional activities in a hormone-dependent manner. PRIP is predominantly expressed in the ovary, brain, testis, and prostate, highlighting its importance in various physiological processes. Notably, PRIP interacts with PRIP-interacting protein with methyltransferase activity (PIMT), facilitating communication between cAMP response element-binding protein-binding protein (CBP) and PPARγ-binding protein-anchored (PBP) co-activator complexes, which are essential for the transcriptional regulation of nuclear receptors. Additionally, PRIP is involved in modulating the phosphorylation of GABAA receptors by inhibiting the phosphatase PP1, thereby influencing synaptic inhibition mediated by these receptors. Anti-PRIP antibody (39-Q) is an invaluable tool for researchers studying the intricate mechanisms of nuclear receptor signaling and its implications in various biological contexts.

The preferred PRIP antibody is PRIP Antibody (E-12): sc-515547.