prefoldin 6 Antibody (F-11): sc-376733
- prefoldin 6 Antibody (F-11) is a mouse monoclonal IgG1 κ prefoldin 6 antibody provided at 200 µg/ml
- raised against amino acids 1-103 mapping at the N-terminus of prefoldin 6 of human origin
- prefoldin 6 Antibody (F-11) is recommended for detection of prefoldin 6 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-prefoldin 6 Antibody (F-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for prefoldin 6 Antibody (F-11) for WB applications. This reagent is now offered in a bundle with prefoldin 6 Antibody (F-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Prefoldin 6 Antibody (F-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects prefoldin 6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-prefoldin 6 antibody (F-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Prefoldin 6 (F-11) monoclonal antibody plays a crucial role in studying the cellular chaperone system, specifically in the proper folding of actin, which is essential for maintaining the structural integrity and functionality of cells. As a heterohexameric chaperone, prefoldin 6 captures unfolded actin and facilitates its transfer to cytosolic chaperonins, ensuring that actin is correctly folded and functional. This process is vital because misfolded proteins can lead to cellular dysfunction and contribute to various diseases. The prefoldin family consists of six polypeptides, each with unique interactions and functions; for instance, prefoldin 1 binds specifically to cytosolic chaperonin, while prefoldin 3 interacts with von Hippel-Lindau protein, highlighting the intricate network of protein interactions that are essential for cellular homeostasis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
prefoldin 6 Antibody (F-11) References:
- Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product. | Tsuchiya, H., et al. 1996. Cancer Res. 56: 2881-5. PMID: 8674032
- Characterization of the gene (VBP1) and transcript for the von Hippel-Lindau binding protein and isolation of the highly conserved murine homologue. | Brinke, A., et al. 1997. Genomics. 45: 105-12. PMID: 9339366
- Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. | Vainberg, IE., et al. 1998. Cell. 93: 863-73. PMID: 9630229
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
prefoldin 6 Antibody (F-11) | sc-376733 | 200 µg/ml | $322.00 | |||
prefoldin 6 Antibody (F-11): m-IgGκ BP-HRP Bundle | sc-523069 | 200 µg Ab, 40 µg BP | $361.00 | |||
prefoldin 6 Antibody (F-11) AC | sc-376733 AC | 500 µg/ml, 25% agarose | $424.00 | |||
prefoldin 6 Antibody (F-11) HRP | sc-376733 HRP | 200 µg/ml | $322.00 | |||
prefoldin 6 Antibody (F-11) FITC | sc-376733 FITC | 200 µg/ml | $336.00 | |||
prefoldin 6 Antibody (F-11) PE | sc-376733 PE | 200 µg/ml | $349.00 | |||
prefoldin 6 Antibody (F-11) Alexa Fluor® 488 | sc-376733 AF488 | 200 µg/ml | $364.00 | |||
prefoldin 6 Antibody (F-11) Alexa Fluor® 546 | sc-376733 AF546 | 200 µg/ml | $364.00 | |||
prefoldin 6 Antibody (F-11) Alexa Fluor® 594 | sc-376733 AF594 | 200 µg/ml | $364.00 | |||
prefoldin 6 Antibody (F-11) Alexa Fluor® 647 | sc-376733 AF647 | 200 µg/ml | $364.00 | |||
prefoldin 6 Antibody (F-11) Alexa Fluor® 680 | sc-376733 AF680 | 200 µg/ml | $364.00 | |||
prefoldin 6 Antibody (F-11) Alexa Fluor® 790 | sc-376733 AF790 | 200 µg/ml | $364.00 |