prefoldin 3 Antibody (YY-3Q): sc-100816
- prefoldin 3 Antibody (YY-3Q) is a mouse monoclonal mouse IgG1 κ κ provided at 100 µg/ml
- raised against recombinant prefoldin 3 of human origin
- recommended for detection of prefoldin 3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for prefoldin 3 Antibody (YY-3Q). This work is in progress.
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Prefoldin 3 Antibody (YY-3Q) is a mouse monoclonal IgG1 antibody that recognizes prefoldin 3 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Prefoldin 3, also known as VHL binding protein-1, plays a crucial role in cellular stress response by facilitating proper protein folding, particularly under conditions where misfolding is prevalent. Prefoldin 3 is primarily located in the cytoplasm and forms complexes with the von Hippel-Lindau (VHL) tumor suppressor protein, which regulates hypoxia-inducible factors and maintains cellular oxygen homeostasis. Anti-prefoldin 3 antibody (YY-3Q) helps researchers study how prefoldin 3 stabilizes VHL and influences hypoxia-inducible factor degradation, impacting processes like angiogenesis and metabolism. Prefoldin 3′s ability to move from perinuclear granules to the nucleus or cytoplasm highlights prefoldin 3′s importance in cellular signaling pathways and stress responses. Anti-prefoldin 3 antibody (YY-3Q) serves as an essential tool for studying protein dynamics and cellular responses across various biological contexts.
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prefoldin 3 Antibody (YY-3Q) References:
- Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development. | Clifford, SC., et al. 1999. Genes Chromosomes Cancer. 26: 20-8. PMID: 10441001
- von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step. | Mousnier, A., et al. 2007. Proc Natl Acad Sci U S A. 104: 13615-20. PMID: 17698809
- Hepatitis B virus X protein enhances NFkappaB activity through cooperating with VBP1. | Kim, SY., et al. 2008. BMB Rep. 41: 158-63. PMID: 18315953
- VBP1 facilitates proteasome and autophagy-mediated degradation of MutS homologue hMSH4. | Xu, Y. and Her, C. 2013. FASEB J. 27: 4799-810. PMID: 23964080
- VBP1 represses cancer metastasis by enhancing HIF-1α degradation induced by pVHL. | Kim, JA., et al. 2018. FEBS J. 285: 115-126. PMID: 29121446
- VBP1 modulates Wnt/β-catenin signaling by mediating the stability of the transcription factors TCF/LEFs. | Zhang, H., et al. 2020. J Biol Chem. 295: 16826-16839. PMID: 32989053
- VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α. | Yue, Y., et al. 2023. J Biol Chem. 299: 104829. PMID: 37201586
- VBP1 promotes tumor proliferation as a part of the hypoxia-related signature in esophageal squamous cell carcinoma. | Miao, H., et al. 2024. Hum Cell. 37: 1141-1155. PMID: 38700744
- Late stage melanoma is hallmarked by low NLGN4X expression leading to HIF1A accumulation. | Schörghofer, D., et al. 2024. Br J Cancer. 131: 468-480. PMID: 38902533
- Expression of the von Hippel-Lindau-binding protein-1 (Vbp1) in fetal and adult mouse tissues. | Hemberger, M., et al. 1999. Hum Mol Genet. 8: 229-36. PMID: 9931330
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
prefoldin 3 Antibody (YY-3Q) | sc-100816 | 100 µg/ml | $339.00 |