PRAS40 Antibody (199H2R): sc-517639
- PRAS40 Antibody (199H2R) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against recombinant PRAS40 of human origin
- recommended for detection of PRAS40 of mouse, rat and human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PRAS40 Antibody (199H2R). This work is in progress.
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SEE ALSO...
PRAS40 Antibody (199H2R) is a mouse monoclonal IgG1 antibody that detects PRAS40 in mouse, rat, and human samples through western blotting (WB). PRAS40, also known as AKT1S1, plays a crucial role in cellular signaling pathways, particularly in the phosphatidylinositol 3-kinase pathway, which regulates various cellular processes including growth, survival, and metabolism. PRAS40 is primarily located in the cytoplasm, where PRAS40 interacts with other signaling molecules, including activated Akt. This interaction influences PRAS40′s phosphorylation state, which affects binding to 14-3-3 proteins. Such binding modulates PRAS40′s subcellular localization and regulates enzymatic activity, impacting cellular responses to growth factors and stress signals. PRAS40′s ability to mediate these processes highlights PRAS40′s importance in neuroprotection and cellular survival, particularly in neuronal cell death following ischemic events. Anti-PRAS40 antibody (199H2R) serves as an invaluable tool for researchers investigating this protein′s intricate roles in various biological contexts.
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRAS40 Antibody (199H2R) | sc-517639 | 100 µg/ml | $322.00 |