PRAM-1 Antibody (H-10): sc-166395

PRAM-1 Antibody (H-10) is a mouse monoclonal IgG2b antibody that detects PRAM-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PRAM-1, or PML-RAR-α target gene encoding an adaptor molecule 1, plays a crucial role in normal human myelopoiesis, acting as an adaptor protein essential for regulating various signaling pathways during hematopoietic development. PRAM-1 expression is significantly modulated by the PML-RAR-α fusion protein, which is implicated in acute promyelocytic leukemia, highlighting PRAM-1′s importance in both normal and pathological states. Structurally, PRAM-1 features eight N-terminal proline-rich repeats and several proline residues that form type I and type II SH3 recognition motifs, which are critical for protein-protein interactions. These structural characteristics enable PRAM-1 to interact with specific proteins involved in signaling cascades, thereby influencing cellular responses and contributing to gene expression regulation during myelopoiesis. PRAM-1 demonstrates expression in hematopoietic tissues and lung, underscoring PRAM-1′s relevance in both normal physiology and disease contexts.

The preferred PRAM-1 antibody is PRAM-1 Antibody (D-11): sc-166267.