PQBP-1 Antibody (G-12): sc-376039

PQBP-1 Antibody (G-12) is a mouse monoclonal IgG2b antibody that detects polyglutamine(Q) tract binding protein-1 (PQBP-1) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PQBP-1 plays a crucial role as a transcription repressor, interacting with polyglutamine tract-containing transcription regulators and genes associated with neurodegenerative disorders, making PQBP-1 vital for understanding the molecular mechanisms underlying these conditions. PQBP-1 is predominantly localized in the nucleus, where PQBP-1 is found in neurons throughout the brain, particularly in regions such as the hippocampus, cerebellar cortex, and olfactory bulb, highlighting PQBP-1′s importance in neuronal function and signaling. PQBP-1′s presence in these areas suggests involvement in critical processes such as synaptic plasticity and memory formation. Additionally, PQBP-1 contains a WWP/WW domain that binds proline-rich motifs and a C2 domain that can influence calcium-dependent phospholipid signaling, further emphasizing PQBP-1′s multifaceted role in cellular signaling pathways. The human PQBP-1 gene is located on chromosome Xp11.23, and PQBP-1′s interactions with specific proteins, including huntingtin and the androgen receptor, underscore PQBP-1′s significance in both normal physiology and the pathology of neurodegenerative diseases.

The preferred PQBP-1 antibody is PQBP-1 Antibody (B-9): sc-374260.