PPX Antibody (C-6): sc-374106

PPX Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects PPX protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PPX (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PPX protein, also known as protein phosphatase 4, plays a crucial role in regulating cellular processes through dephosphorylation, which is essential for maintaining cellular homeostasis and cell cycle progression. Located primarily in the nucleus, PPX is involved in various cellular functions, including DNA repair and gene expression regulation, making PPX vital for cellular integrity and stress response. PPX′s unique structure, which includes a catalytic domain distinct from other protein phosphatases, enables interaction with specific substrates and regulatory proteins, influencing various signaling pathways. Understanding PPX′s function and interactions helps elucidate PPX′s role in cellular signaling and potential implications in diseases where these pathways are disrupted.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PPX Antibody (C-6) References:

1. Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B).  |  Ueki, K., et al. 1992. Biochem Biophys Res Commun. 187: 537-43. PMID: 1325794
2. The Protein Phosphatase 4 Complex Functions in miRNA Biogenesis in Arabidopsis.  |  Hammond, RK. 2019. Plant Cell. 31: 278-279. PMID: 30712007
3. Expression of protein phosphatase 4 in different tissues under hypoxia.  |  Ma, Y., et al. 2023. Indian J Pathol Microbiol. 66: 577-583. PMID: 37530343
4. Fitusiran prophylaxis in people with hemophilia A or B who switched from prior BPA/CFC prophylaxis: the ATLAS-PPX trial.  |  Kenet, G., et al. 2024. Blood. 143: 2256-2269. PMID: 38452197
5. Protein phosphatase 4 mediates palmitic acid-induced endothelial dysfunction by decreasing eNOS phosphorylation at serine 633 in HUVECs.  |  Liang, Z., et al. 2024. Exp Cell Res. 437: 113998. PMID: 38513962
6. Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes.  |  Dong, MZ., et al. 2024. Cell Death Dis. 15: 658. PMID: 39245708
7. Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing.  |  Van Eynde, A., et al. 1995. J Biol Chem. 270: 28068-74. PMID: 7499293
8. Serine/threonine protein phosphatases.  |  Wera, S. and Hemmings, BA. 1995. Biochem J. 311 (Pt 1): 17-29. PMID: 7575450
9. Important roles for novel protein phosphatases dephosphorylating serine and threonine residues.  |  Cohen, PT. 1993. Biochem Soc Trans. 21: 884-8. PMID: 8132087
10. A regulatory subunit of smooth muscle myosin bound phosphatase.  |  Okubo, S., et al. 1994. Biochem Biophys Res Commun. 200: 429-34. PMID: 8166716
11. Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing.  |  Hendrix, P., et al. 1993. J Biol Chem. 268: 15267-76. PMID: 8392071
12. Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth.  |  Mumby, MC. and Walter, G. 1993. Physiol Rev. 73: 673-99. PMID: 8415923

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PPX Antibody (C-6) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-PPX Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PPX Antibody (C-6) Specifications

Alternate Product Name: PPX

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 275-298

Epitope Target: PPX

Epitope Species: human

Product Reactivity/Detection: PPX

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for PPX Antibody (C-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin