PPIL2 Antibody (H-2): sc-398201
- PPIL2 Antibody (H-2) is a mouse monoclonal IgG1 κ PPIL2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 346-369 within an internal region of PPIL2 of human origin
- PPIL2 Antibody (H-2) is recommended for detection of PPIL2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and porcine
- Anti-PPIL2 Antibody (H-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PPIL2 Antibody (H-2) for WB applications. These reagents are now offered in bundles with PPIL2 Antibody (H-2) (see ordering information below).
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PPIL2 Antibody (H-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects PPIL2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PPIL2 (H-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PPIL2 protein, also known as cyclophilin-60, is a crucial peptidylprolyl isomerase that plays a significant role in protein folding by catalyzing the cis-trans isomerization of proline residues within polypeptides. This function is vital for proper folding and stability of proteins, which is essential for maintaining cellular homeostasis and function. Cyclophilin-60 is predominantly expressed in testis, pancreas, and placenta, and expression is also noted in various cancers, including melanomas and lymphomas, highlighting potential role in tumor biology. The gene encoding cyclophilin-60 is located on human chromosome 22q11.21, and exists in two alternatively spliced isoforms, further emphasizing complexity and importance in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PPIL2 Antibody (H-2) References:
- U box proteins as a new family of ubiquitin-protein ligases. | Hatakeyama, S., et al. 2001. J Biol Chem. 276: 33111-20. PMID: 11435423
- Roles of cyclophilins in cancers and other organ systems. | Yao, Q., et al. 2005. World J Surg. 29: 276-80. PMID: 15706440
- Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60. | Pushkarsky, T., et al. 2005. J Biol Chem. 280: 27866-71. PMID: 15946952
- Variation in RTN3 and PPIL2 genes does not influence platelet membrane beta-secretase activity or susceptibility to alzheimer's disease in the northern Irish population. | Carson, R., et al. 2009. Neuromolecular Med. 11: 337-44. PMID: 19669607
- Identification of a nuclear-specific cyclophilin which interacts with the proteinase inhibitor eglin c. | Wang, BB., et al. 1996. Biochem J. 314 (Pt 1): 313-9. PMID: 8660300
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PPIL2 Antibody (H-2) | sc-398201 | 200 µg/ml | $322.00 | |||
PPIL2 Antibody (H-2): m-IgG Fc BP-HRP Bundle | sc-527748 | 200 µg Ab; 10 µg BP | $361.00 | |||
PPIL2 Antibody (H-2): m-IgG1 BP-HRP Bundle | sc-533121 | 200 µg Ab; 20 µg BP | $361.00 | |||
PPIL2 Antibody (H-2) AC | sc-398201 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PPIL2 Antibody (H-2) HRP | sc-398201 HRP | 200 µg/ml | $322.00 | |||
PPIL2 Antibody (H-2) FITC | sc-398201 FITC | 200 µg/ml | $336.00 | |||
PPIL2 Antibody (H-2) PE | sc-398201 PE | 200 µg/ml | $349.00 | |||
PPIL2 Antibody (H-2) Alexa Fluor® 488 | sc-398201 AF488 | 200 µg/ml | $364.00 | |||
PPIL2 Antibody (H-2) Alexa Fluor® 546 | sc-398201 AF546 | 200 µg/ml | $364.00 | |||
PPIL2 Antibody (H-2) Alexa Fluor® 594 | sc-398201 AF594 | 200 µg/ml | $364.00 | |||
PPIL2 Antibody (H-2) Alexa Fluor® 647 | sc-398201 AF647 | 200 µg/ml | $364.00 | |||
PPIL2 Antibody (H-2) Alexa Fluor® 680 | sc-398201 AF680 | 200 µg/ml | $364.00 | |||
PPIL2 Antibody (H-2) Alexa Fluor® 790 | sc-398201 AF790 | 200 µg/ml | $364.00 | |||
PPIL2 (H-2) Neutralizing Peptide | sc-398201 P | 100 µg/0.5 ml | $69.00 |