PPEF-1/PP7/PPEF1 Antibody (SW-67): sc-134424

PPEF-1 Antibody (SW-67) is a mouse monoclonal IgG1 kappa light chain antibody that detects the PPEF-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PPEF-1 antibody (SW-67) is available as the non-conjugated form. PPEF-1, also known as protein protease with EF-hand motifs 1, plays a crucial role as a serine/threonine protein phosphatase, which is essential for various cellular processes, including signal transduction and cellular regulation. PPEF-1 is predominantly expressed in the brain, with particularly high levels observed in fetal brain tissue, as well as in sensory neurons of the dorsal root ganglia and cranial ganglia derived from neural crest cells. This expression pattern suggests a vital role for PPEF-1 in the development and function of the nervous system, particularly in sensory processing. The gene encoding PPEF-1 is located on human chromosome Xp22.2-p22.1 and is highly homologous to the Drosophila retinal degeneration gene C (rdgC), which is critical for preventing light-induced retinal degeneration. While the loss of rdgC function in Drosophila leads to retinal degeneration, studies have shown that the elimination of PPEF function does not result in similar degeneration in vertebrates, indicating a divergence in the functional roles of these homologous proteins across species.

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PPEF-1/PP7/PPEF1 Antibody (SW-67) References:

1. Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2).  |  Ramulu, P., et al. 2001. Mol Cell Biol. 21: 8605-14. PMID: 11713293
2. A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin.  |  Montini, E., et al. 1997. Hum Mol Genet. 6: 1137-45. PMID: 9215685
3. Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C.  |  Sherman, PM., et al. 1997. Proc Natl Acad Sci U S A. 94: 11639-44. PMID: 9326663