PP2Cα Antibody (p6c7): sc-56956

PP2Cα Antibody (p6c7) is a mouse monoclonal IgG2b antibody that detects PP2Cα in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PP2Cα plays a crucial role in cellular signaling by acting as a serine/threonine protein phosphatase, which is essential for the regulation of various cellular functions, including cell division, homeostasis, and apoptosis. PP2Cα′s ability to dephosphorylate key signaling molecules, such as MAP kinases and MAP kinase-kinases, is vital for maintaining cellular responses to environmental stresses, thereby preventing aberrant cell signaling that could lead to diseases such as cancer. Additionally, PP2Cα induces the expression of the tumor suppressor protein p53 and its downstream target p21, which are critical for mediating cell cycle arrest and apoptosis in response to cellular stress. PP2Cα is predominantly expressed in epithelial cells and is found in various tissues, including the digestive tract, lung, kidney, breast, prostate, endocrine glands, and brain, highlighting its importance in both normal physiology and disease states. With broad specificity and significant regulatory functions, PP2Cα is a key player in cellular signaling pathways, making anti-PP2Cα antibody (p6c7) an invaluable tool for researchers studying these critical processes.

The preferred PP2Cα/β antibody is PP2Cα/β Antibody (D-8): sc-166662.