PP2Cα Antibody (6D708): sc-71922

PP2Cα Antibody (6D708) is a mouse monoclonal IgG2b antibody that detects PP2Cα in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). PP2Cα plays a crucial role in cellular signaling by acting as a serine/threonine protein phosphatase, which is essential for the regulation of various cellular functions, including cell division, homeostasis, and apoptosis. PP2Cα′s ability to dephosphorylate key signaling molecules, such as MAP kinases and MAP kinase-kinases, is vital for maintaining cellular responses to environmental stresses, thereby preventing uncontrolled cell proliferation and promoting cell survival. PP2Cα is predominantly expressed in epithelial cells and is found in various tissues, including the digestive tract, lung, kidney, breast, prostate, endocrine glands, and brain, highlighting its importance in both normal physiology and potential pathological conditions. The unique structure of PP2Cα, characterized by its dinuclear metal ion center in the active site, is critical for its enzymatic function, allowing PP2Cα to effectively modulate the phosphorylation state of target proteins. With its broad specificity and significant regulatory roles, PP2Cα is a key player in cellular signaling pathways, making anti-PP2Cα antibody (6D708) an invaluable tool for researchers studying these complex processes.

The preferred PP2Cα/β antibody is PP2Cα/β Antibody (D-8): sc-166662.