PP2B-B1 Antibody (70-A): sc-130393
- PP2B-B1 Antibody (70-A) is a mouse monoclonal IgG1 κ PP2B-B1 antibody provided at 100 µg/ml
- raised against recombinant PP2B-B1 of human origin
- recommended for detection of PP2B-B1 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PP2B-B1 Antibody (70-A). This work is in progress.
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PP2B-B1 Antibody (70-A) is a mouse monoclonal IgG1 kappa light chain antibody that detects PP2B-B1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PP2B-B1 antibody (70-A) is available as the non-conjugated format. PP2B-B1 plays a crucial role in regulating cellular signaling pathways, particularly in calcium-dependent processes. PP2B-B1 functions as a regulatory subunit of the protein phosphatase 2B (PP2B) complex, which is essential for dephosphorylating serine and threonine residues on target proteins, influencing various cellular functions such as muscle contraction, immune response, and neuronal signaling. PP2B-B1 maintains cellular homeostasis and ensures signaling pathways are accurately modulated in response to physiological stimuli. Dysregulation of PP2B-B1 has been implicated in several diseases, including neurodegenerative disorders and cancer, highlighting PP2B-B1′s importance as a potential therapeutic target. Through interactions with various proteins within the phosphatase complex, PP2B-B1 serves as a key player in the intricate network of cellular signaling, making PP2B-B1 an important focus for research in cell biology and pharmacology.
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PP2B-B1 Antibody (70-A) References:
- Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B). | Ueki, K., et al. 1992. Biochem Biophys Res Commun. 187: 537-43. PMID: 1325794
- Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing. | Van Eynde, A., et al. 1995. J Biol Chem. 270: 28068-74. PMID: 7499293
- Serine/threonine protein phosphatases. | Wera, S. and Hemmings, BA. 1995. Biochem J. 311 (Pt 1): 17-29. PMID: 7575450
- Important roles for novel protein phosphatases dephosphorylating serine and threonine residues. | Cohen, PT. 1993. Biochem Soc Trans. 21: 884-8. PMID: 8132087
- A regulatory subunit of smooth muscle myosin bound phosphatase. | Okubo, S., et al. 1994. Biochem Biophys Res Commun. 200: 429-34. PMID: 8166716
- Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing. | Hendrix, P., et al. 1993. J Biol Chem. 268: 15267-76. PMID: 8392071
- Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth. | Mumby, MC. and Walter, G. 1993. Physiol Rev. 73: 673-99. PMID: 8415923
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP2B-B1 Antibody (70-A) | sc-130393 | 100 µg/ml | $333.00 |