PP2A-C alpha / beta Antibody (C-1): sc-376673
- PP2A-Cα/β Antibody (C-1) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-309 representing full length PP2A-Cα isoform of PP2A-Cα
- recommended for detection of PP2A-Cα/β of mouse, rat, human and origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine, porcine and avian
- See PP2A-Cα/β (1D6): sc-80665 for PP2A-Cα/β antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PP2A-Cα/β Antibody (C-1) for WB applications. These reagents are now offered in bundles with PP2A-Cα/β Antibody (C-1) (see ordering information below).
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PP2A-Cα/β Antibody (C-1) is a mouse monoclonal IgG1 antibody that detects PP2A-Cα/β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PP2A-Cα/β is a critical component of the protein phosphatase 2A (PP2A) family, which plays a vital role in cellular signaling by dephosphorylating serine and threonine residues on target proteins, thereby regulating various cellular processes including cell division, apoptosis, and metabolic homeostasis. The structure of PP2A is particularly important as PP2A forms a trimeric complex composed of a catalytic subunit, a regulatory subunit, and a variable subunit, which together create a highly versatile enzyme capable of interacting with numerous substrates. This structural complexity allows PP2A to modulate a wide array of signaling pathways, making PP2A essential for maintaining cellular function and responding to external stimuli. The ability of PP2A to form different holoenzyme configurations through regulatory subunits, such as PP2A-Aα and PP2A-B56α, further enhances functional diversity, allowing PP2A to fine-tune cellular responses and maintain homeostasis. Anti-PP2A-Cα/β antibody (C-1) is therefore an invaluable tool for researchers studying the intricate roles of protein phosphatases in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PP2A-C alpha / beta Antibody (C-1) References:
- Protein phosphatase 2A (PP2A), a drugable tumor suppressor in Ph1(+) leukemias. | Perrotti, D. and Neviani, P. 2008. Cancer Metastasis Rev. 27: 159-68. PMID: 18213449
- PP2A in meiotic oocytes. | Yan, X. and Zhu, X. 2016. Cell Cycle. 15: 1950-1. PMID: 27210114
- Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1. | Kaur, A. and Westermarck, J. 2016. Biochem Soc Trans. 44: 1683-1693. PMID: 27913678
- Protein phosphatase PP2A regulates microtubule orientation and dendrite pruning in Drosophila. | Rui, M., et al. 2020. EMBO Rep. 21: e48843. PMID: 32187821
- Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System. | Bryant, JP., et al. 2021. Cancers (Basel). 13: PMID: 34205611
- Interaction mechanism of endogenous PP2A inhibitor protein ENSA with PP2A. | Thapa, C., et al. 2022. FEBS J. 289: 519-534. PMID: 34346186
- Renal AT2 Receptors Mediate Natriuresis via Protein Phosphatase PP2A. | Kemp, BA., et al. 2022. Circ Res. 130: 96-111. PMID: 34794320
- RAS and PP2A activities converge on epigenetic gene regulation. | Aakula, A., et al. 2023. Life Sci Alliance. 6: PMID: 36858798
- Molecular Mechanism of PP2A/B55α Phosphatase Inhibition by IER5. | Cao, R., et al. 2024. bioRxiv.. PMID: 37693604
- Correction: PP2A inhibition overcomes acquired resistance to HER2 targeted therapy. | McDermott, MSJ., et al. 2023. Mol Cancer. 22: 175. PMID: 37915024
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP2A-Cα/β Antibody (C-1) | sc-376673 | 200 µg/ml | $322.00 | |||
PP2A-Cα/β Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-537995 | 200 µg Ab; 10 µg BP | $361.00 | |||
PP2A-Cα/β Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-535501 | 200 µg Ab; 40 µg BP | $361.00 | |||
PP2A-Cα/β Antibody (C-1): m-IgG1 BP-HRP Bundle | sc-545480 | 200 µg Ab; 20 µg BP | $361.00 |