PP2A-B55-γ Antibody (OS-5): sc-100417

PP2A-B55-γ Antibody (OS-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects PP2A-B55-gamma protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PP2A-B55-gamma antibody (OS-5) is available as a non-conjugated format. PP2A-B55-gamma protein, also known as PPP2R2C, plays a crucial role in regulating various cellular processes through dephosphorylation of serine and threonine residues on target proteins. This regulatory subunit is part of the larger protein phosphatase 2A (PP2A) complex, essential for maintaining cellular homeostasis, controlling cell division, and regulating apoptosis. The B55 subfamily, to which PP2A-B55-γ belongs, is particularly important for determining substrate specificity and catalytic activity within the PP2A holoenzyme, a trimeric complex composed of regulatory, variable, and catalytic subunits. PP2A-B55-γ interaction with various catalytic subunits allows precise control over signaling pathways, making PP2A-B55-γ a vital component in cellular function and a significant target for research in cancer and other diseases where these pathways are dysregulated.

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PP2A-B55-γ Antibody (OS-5) References:

1. Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55.  |  Turowski, P., et al. 1999. Mol Biol Cell. 10: 1997-2015. PMID: 10359611
2. Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.  |  Hrimech, M., et al. 2000. EMBO J. 19: 3956-67. PMID: 10921877
3. Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16.  |  Hu, P., et al. 2000. Genomics. 67: 83-6. PMID: 10945473
4. ATM-dependent dissociation of B55 regulatory subunit from nuclear PP2A in response to ionizing radiation.  |  Guo, CY., et al. 2002. J Biol Chem. 277: 4839-44. PMID: 11723136
5. Fine mapping a quantitative trait locus affecting ovulation rate in swine on chromosome 8.  |  Campbell, EM., et al. 2003. J Anim Sci. 81: 1706-14. PMID: 12854806
6. Using the Ras Recruitment System to identify PP2A-B55-interacting proteins.  |  Barr, HM., et al. 2003. Methods Enzymol. 366: 175-87. PMID: 14674249
7. PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder.  |  Borsotto, M., et al. 2007. Pharmacogenomics J. 7: 123-32. PMID: 16733521
8. Mitochondrial protein phosphatase 2A regulates cell death induced by simulated ischemia in kidney NRK-52E cells.  |  Tsao, CC., et al. 2007. Cell Cycle. 6: 2377-85. PMID: 17700073
9. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.  |  McCright, B., et al. 1996. J Biol Chem. 271: 22081-9. PMID: 8703017

The preferred PP2A-B55 antibody is PP2A-B55 Antibody (D-10): sc-365282.