PP1β Antibody (G-4): sc-373783
- PP1β Antibody (G-4) is a mouse monoclonal IgA κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 295-322 at the C-terminus of PP1β of human origin
- recommended for detection of PP1β of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine, bovine, porcine and avian
- See PP1 (E-9): sc-7482 for PP1β antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PP1β Antibody (G-4). This work is in progress.
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PP1β Antibody (G-4) is a mouse monoclonal IgA kappa light chain antibody engineered to recognize an epitope spanning amino acids 295-322 at the C-terminus of the human Protein Phosphatase 1 Beta (PP1β), also known as PPP1CB. PP1β monoclonal antibody (G-4) exhibits broad species reactivity, effectively detecting PP1β from mouse, rat, human, avian, canine, bovine, and porcine origins through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Available in both non-conjugated and multiple conjugated forms such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, anti-PP1β antibody (G-4) provides versatile options to accommodate diverse experimental needs. PP1β is a crucial catalytic subunit within the Protein Phosphatase 1 (PP1) family, characterized by its conserved catalytic domain essential for serine/threonine phosphatase activity and a unique C-terminal region that facilitates interactions with regulatory and targeting proteins. PP1β interacts with several key proteins, including inhibitor-2 (I-2), spinophilin, and MYPT1, which are vital for regulation and localization within the cell. These interactions are critical for modulating PP1β′s activity, ensuring precise dephosphorylation of substrates involved in processes such as cell cycle progression, muscle contraction, and neuronal signaling. PP1β forms complexes with regulatory proteins like NIPP-1 and PNUTS, which control phosphatase activity and substrate specificity, thereby playing an essential role in maintaining cellular homeostasis and responding to various signaling pathways. Understanding the interactions between PP1β and binding partners is fundamental for elucidating roles in diverse cellular functions and involvement in pathological conditions such as cancer and neurodegenerative diseases. Anti-PP1β antibody (G-4) enables researchers to effectively study these protein-protein interactions, gain deeper insights into regulatory mechanisms governing PP1β activity, and explore impact on cellular signaling networks.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP1β Antibody (G-4) | sc-373783 | 200 µg/ml | $316.00 | |||
PP1β (G-4) Neutralizing Peptide | sc-373783 P | 100 µg/0.5 ml | $68.00 |