PP1β Antibody (D-11): sc-377125
- PP1β Antibody (D-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-31 at the N-terminus of PP1β of human origin
- recommended for detection of PP1β of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine, bovine, porcine and avian
- See PP1 (E-9): sc-7482 for PP1β antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PP1β Antibody (D-11) for WB and IHC(P) applications. These reagents are now offered in bundles with PP1β Antibody (D-11) (see ordering information below).
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PP1β Antibody (D-11) is a mouse monoclonal IgG1 kappa light chain antibody engineered to recognize an epitope mapping between amino acids 2-31 at the N-terminus of human Protein Phosphatase 1 Beta (PP1β), also known as PPP1CB. PP1β is a pivotal catalytic subunit of the Protein Phosphatase 1 (PP1) family, playing a crucial role in the regulation of numerous cellular processes by dephosphorylating serine and threonine residues on target proteins. This enzymatic activity is essential for controlling vital functions such as cell division, metabolism, homeostasis, and apoptosis, thereby maintaining cellular balance and enabling appropriate responses to various cellular signals. The structural integrity of PP1β, particularly its N-terminal region where the epitope is located, is vital for interaction with regulatory and targeting proteins, ensuring precise localization and function within both the nucleus and cytoplasm of eukaryotic cells. Dysregulation of PP1β activity has been implicated in several diseases, including cancer and neurodegenerative disorders, highlighting its significance as a potential therapeutic target. Anti-PP1β antibody (D-11) demonstrates broad species reactivity, effectively detecting PP1β proteins from mouse, rat, human, and avian origins, as well as additional species including canine, bovine, and porcine, across multiple applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Available in both non-conjugated form and various conjugated forms including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, PP1β (D-11) antibody offers researchers versatile options to meet diverse experimental needs. By enabling accurate detection and analysis of PP1β, PP1β monoclonal antibody (D-11) facilitates a deeper understanding of PP1β′s role in cellular signaling networks and implications in both physiological and pathological contexts, making anti-PP1β antibody (D-11) an indispensable tool for advancing research into protein phosphatase function and regulation within diverse biological systems.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP1β Antibody (D-11) | sc-377125 | 200 µg/ml | $316.00 | |||
PP1β Antibody (D-11): m-IgG Fc BP-HRP Bundle | sc-540695 | 200 µg Ab; 10 µg BP | $354.00 | |||
PP1β Antibody (D-11): m-IgG1 BP-HRP Bundle | sc-542304 | 200 µg Ab; 20 µg BP | $354.00 | |||
PP1β (D-11) Neutralizing Peptide | sc-377125 P | 100 µg/0.5 ml | $68.00 |