PON2 Antibody (D-12): sc-373981
- PON2 Antibody (D-12) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 61-113 mapping within an internal region of PON2 of human origin
- recommended for detection of PON2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for PON2 Antibody (D-12) for WB and IHC(P) applications. These reagents are now offered in bundles with PON2 Antibody (D-12) (see ordering information below).
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PON2 Antibody (D-12) is a mouse monoclonal IgG2a antibody that detects PON2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). PON2, or paraoxonase 2, plays a crucial role in the hydrolysis of organophosphates and is involved in the detoxification of harmful compounds, which is vital for protecting cells from oxidative stress and inflammation. PON2 is predominantly located in the endoplasmic reticulum of various tissues, including the pancreas, where PON2 contributes to lipid metabolism and cellular defense mechanisms. PON2′s presence in these tissues underscores PON2′s importance in maintaining cellular homeostasis and preventing damage from reactive oxygen species. Anti-PON2 antibody (D-12) is an essential tool for researchers studying the physiological and pathological roles of PON2, enabling insights into PON2′s function and potential therapeutic applications in conditions related to oxidative stress and organophosphate exposure.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PON2 Antibody (D-12) References:
- The roles of PON1 and PON2 in cardiovascular disease and innate immunity. | Shih, DM. and Lusis, AJ. 2009. Curr Opin Lipidol. 20: 288-92. PMID: 19474728
- Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection. | Costa, LG., et al. 2014. Neurotoxicology. 43: 3-9. PMID: 24012887
- PON2 and PPARG polymorphisms as biomarkers of risk for coronary heart disease. | González-Castro, TB., et al. 2018. Biomark Med. 12: 287-297. PMID: 29441810
- PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. | Shih, DM., et al. 2019. Antioxidants (Basel). 8: PMID: 30641857
- PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis. | Pan, L., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33531346
- PON2 blockade overcomes dexamethasone resistance in acute lymphoblastic leukemia. | Hui, PY., et al. 2022. Hematology. 27: 32-42. PMID: 34957927
- PON2 mediates mitochondrial dysfunction in tracheal epithelial cells in response to a quorum sensing molecule N-(-3-oxododecanoyl)-l-homoserine lactone. | Whitt, AG., et al. 2022. Biochem J. 479: 2013-2034. PMID: 36094147
- Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation. | Karlov, VD., et al. 2023. Dokl Biochem Biophys. 508: 31-36. PMID: 36653584
- Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis. | Whitt, AG., et al. 2023. Sci Rep. 13: 9929. PMID: 37337025
- Antiapoptotic PON2 expression and its clinical implications in locally advanced oral squamous cell carcinoma. | Kamal, MV., et al. 2024. Cancer Sci. 115: 2012-2022. PMID: 38602182
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PON2 Antibody (D-12) | sc-373981 | 200 µg/ml | $316.00 | |||
PON2 Antibody (D-12): m-IgG Fc BP-HRP Bundle | sc-540410 | 200 µg Ab; 10 µg BP | $354.00 | |||
PON2 Antibody (D-12): m-IgG2a BP-HRP Bundle | sc-546904 | 200 µg Ab; 10 µg BP | $354.00 |