Poliovirus Type 3 Antibody (45D5): sc-80503

Poliovirus Type 3 Antibody (45D5) is a mouse monoclonal IgG2a kappa light chain antibody that detects Poliovirus Type 3 protein of Poliovirus origin by enzyme-linked immunosorbent assay (ELISA). Anti-Poliovirus Type 3 antibody (45D5) is available as a non-conjugated format. Poliovirus Type 3 protein plays a crucial role in poliomyelitis pathogenesis, an infectious disease causing severe neurological complications, including muscle weakness and paralysis. Poliovirus Type 3 protein enables viral replication and spread within hosts by facilitating virus entry into host cells and cytoplasmic replication. Understanding Poliovirus Type 3 protein function remains vital for developing effective vaccines and therapeutic strategies against polio, particularly in endemic regions. Poliomyelitis, commonly known as polio, transmits through fecal-oral routes and can cause serious health issues, including respiratory failure due to intercostal muscle and diaphragm paralysis. Poliovirus, classified as a small RNA picorna-enterovirus, primarily targets gastrointestinal-associated lymphoid tissue (GALT). Three distinct virus types exist: Type 1, Type 2, and Type 3, each with varying epidemiological significance.

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Poliovirus Type 3 Antibody (45D5) References:

1. Trial of a supplemental dose of four poliovirus vaccines.  |  Sutter, RW., et al. 2000. N Engl J Med. 343: 767-73. PMID: 10984564
2. Muscular effects in late polio.  |  Sunnerhagen, KS. and Grimby, G. 2001. Acta Physiol Scand. 171: 335-40. PMID: 11412146
3. Seroprevalence to polio in personnel at a virology institute.  |  Schoub, BD., et al. 2001. J Infect. 43: 128-31. PMID: 11676519
4. Characterization of formaldehyde-inactivated poliovirus preparations made from live-attenuated strains.  |  Martín, J., et al. 2003. J Gen Virol. 84: 1781-1788. PMID: 12810872
5. Immunogenicity and reactogenicity of four doses of diphtheria-tetanus-three-component acellular pertussis-hepatitis B-inactivated polio virus-Haemophilus influenzae type b vaccine coadministered with 7-valent pneumococcal conjugate Vaccine.  |  Tichmann-Schumann, I., et al. 2005. Pediatr Infect Dis J. 24: 70-7. PMID: 15665713
6. Infectious disease. Polio experts strive to understand a puzzling outbreak.  |  Roberts, L. 2006. Science. 312: 1581. PMID: 16778026
7. Universal use of inactivated polio vaccine.  |  Falleiros Carvalho, LH. and Weckx, LY. 2006. J Pediatr (Rio J). 82: S75-82. PMID: 16794745
8. Approaches to the construction of new candidate poliovirus type 3 vaccine strains.  |  Almond, JW., et al. 1993. Dev Biol Stand. 78: 161-9; discussion 169-70. PMID: 8388827
9. Clinical acceptability and immunogenicity of a pentavalent parenteral combination vaccine containing diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis and Haemophilus influenzae type b conjugate antigens in two-, four- and six-month-old Chilean infants.  |  Lagos, R., et al. 1998. Pediatr Infect Dis J. 17: 294-304. PMID: 9576383

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Poliovirus Type 3 Antibody (45D5) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Poliovirus Type 3 Antibody (45D5) Specifications

Alternate Product Name: Poliovirus Type 3

Product Clone Name: 45D5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: Poliovirus Type 3

Epitope Species: Poliovirus Type 3

Product Reactivity/Detection: Poliovirus Type 3

Species Reactivity/Detection: Poliovirus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Poliovirus Type 3 Antibody (45D5): N/A