PNS Myelin Antibody (2B5): sc-69894
- PNS Myelin Antibody (2B5) is a mouse monoclonal IgM PNS Myelin antibody provided at 500 µl ascites
- raised against myelin isolated from the peripheral nervous system of human origin
- recommended for detection of myelin in the PNS of human origin by WB, IF and IHC(P); may cross-react with myelin in the CNS
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PNS Myelin Antibody (2B5). This work is in progress.
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PNS Myelin Antibody (2B5) is a mouse monoclonal IgM antibody that detects the PNS Myelin protein of human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry. Anti-PNS Myelin antibody (2B5) is available as the non-conjugated form. Myelin, primarily composed of approximately 80% lipid and 20% protein, serves as a crucial insulating layer around neuronal axons, significantly enhancing the speed of electrical impulse transmission. This insulation is vital for the proper functioning of the nervous system, as myelinated neurons exhibit a higher rate of regeneration and maintain electrical current more effectively than their unmyelinated counterparts. Myelin is synthesized in the central nervous system (CNS) by oligodendrocytes and in the peripheral nervous system (PNS) by Schwann cells, also known as neurolemmocytes. The integrity of the myelin sheath is essential; its loss, a condition known as demyelination, can lead to severe neurological symptoms such as double vision, speech difficulties, loss of dexterity, and heightened sensitivity to heat. Demyelination is associated with various neurological disorders, including leukodystrophy and multiple sclerosis. Understanding the structural differences between CNS Myelin and PNS Myelin is critical for unraveling the pathogenesis of these complex diseases, and PNS Myelin (2B5) antibody plays a vital role in this research by enabling the study of myelin′s function and its implications in health and disease.
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PNS Myelin Antibody (2B5) References:
- Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice. | Pan, B., et al. 2005. Exp Neurol. 195: 208-17. PMID: 15953602
- Evolution of a neuroprotective function of central nervous system myelin. | Yin, X., et al. 2006. J Cell Biol. 172: 469-78. PMID: 16449196
- Expression of a myelin proteolipid protein (Plp)-lacZ transgene is reduced in both the CNS and PNS of Plp(jp) mice. | Wight, PA., et al. 2007. Neurochem Res. 32: 343-51. PMID: 17191136
- Isolation of myelin. | Larocca, JN. and Norton, WT. 2007. Curr Protoc Cell Biol. Chapter 3: Unit3.25. PMID: 18228513
- A hypothesis about the relationship of myelin-associated glycoprotein's function in myelinated axons to its capacity to inhibit neurite outgrowth. | Quarles, RH. 2009. Neurochem Res. 34: 79-86. PMID: 18408997
- Myelin repair strategies: a cellular view. | Gallo, V. and Armstrong, RC. 2008. Curr Opin Neurol. 21: 278-83. PMID: 18451710
- Switching myelination on and off. | Salzer, JL. 2008. J Cell Biol. 181: 575-7. PMID: 18490509
- c-Jun is a negative regulator of myelination. | Parkinson, DB., et al. 2008. J Cell Biol. 181: 625-37. PMID: 18490512
- Monoclonal antibody selectively reactive with myelin sheaths of the peripheral nervous system in paraffin-embedded material. | van Dijk, WR., et al. 1986. Acta Neuropathol. 71: 311-5. PMID: 2432751
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PNS Myelin Antibody (2B5) | sc-69894 | 500 µl ascites | $322.00 |