PMR1 Antibody (G-9): sc-365375

PMR1 Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects PMR1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PMR1 (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PMR1 protein, also known as ATP2C1 in humans, encodes a P-type calcium transport ATPase primarily localized to the Golgi apparatus, where PMR1 plays a crucial role in regulating intracellular calcium and manganese transport. This regulation is vital for numerous cellular processes, including signal transduction, muscle contraction, and neurotransmitter release. PMR1 protein is a transmembrane protein that exists in two splice variants differing by 20 amino acids, and PMR1 dysfunction is implicated in Hailey-Hailey disease, an autosomal dominant disorder characterized by skin blisters and erosions. PMR1 interaction with other P-type ATPases, such as the sarco(endo)plasmic calcium ATPase and the plasma membrane calcium ATPase, further underscores PMR1′s importance in maintaining cellular calcium homeostasis. These insights into PMR1 protein highlight PMR1′s essential role in cellular integrity and signaling, making anti-PMR1 antibody (G-9) a valuable tool for researchers studying calcium transport mechanisms and related pathologies.

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PMR1 Antibody (G-9) References:

1. An N-terminal EF hand-like motif modulates ion transport by Pmr1, the yeast Golgi Ca(2+)/Mn(2+)-ATPase.  |  Wei, Y., et al. 1999. Biochemistry. 38: 14534-41. PMID: 10545175
2. Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease.  |  Hu, Z., et al. 2000. Nat Genet. 24: 61-5. PMID: 10615129
3. Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump.  |  Sudbrak, R., et al. 2000. Hum Mol Genet. 9: 1131-40. PMID: 10767338
4. Molecular cloning and tissue distribution of alternatively spliced mRNAs encoding possible mammalian homologues of the yeast secretory pathway calcium pump.  |  Gunteski-Hamblin, AM., et al. 1992. Biochemistry. 31: 7600-8. PMID: 1380825
5. PMR1, a Ca2+-ATPase in yeast Golgi, has properties distinct from sarco/endoplasmic reticulum and plasma membrane calcium pumps.  |  Sorin, A., et al. 1997. J Biol Chem. 272: 9895-901. PMID: 9092527

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PMR1 Antibody (G-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PMR1 Antibody (G-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PMR1 Antibody (G-9) Specifications

Alternate Product Name: PMR1

Product Clone Name: G-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 720-919

Epitope Target: PMR1

Epitope Species: human

Product Reactivity/Detection: PMR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PMR1 Antibody (G-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin