PLP Antibody (853I2F): sc-517649

PLP Antibody (853I2F) is a mouse monoclonal IgM antibody that detects PLP protein of mouse, rat, and human origin by western blotting (WB). Anti-PLP antibody (853I2F) is available as the non-conjugated form. The myelin proteolipid protein (PLP) plays a crucial role in the formation and maintenance of myelin sheaths in the central nervous system, which are essential for proper conduction of electrical impulses along nerve fibers. PLP is predominantly located in oligodendrocytes, where PLP contributes to the structural integrity of myelin, accounting for approximately half of the protein content in adult central nervous system myelin. Mutations in the gene encoding PLP are associated with Pelizaeus-Merzbacher disease (PMD), a severe neurological disorder that affects myelination in the brain and leads to significant developmental challenges. The gene for PLP is located on human chromosome Xq22, highlighting PLP′s importance in both genetic studies and potential therapeutic targets for demyelinating diseases. Additionally, PLP interacts with other myelin proteins, such as glycoprotein zero and peripheral myelin protein 22, which further underscores PLP′s significance in myelin structure and function.

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PLP Antibody (853I2F) References:

1. The gene for the peripheral myelin protein PMP-22 is a candidate for Charcot-Marie-Tooth disease type 1A.  |  Patel, PI., et al. 1992. Nat Genet. 1: 159-65. PMID: 1303228
2. A leucine-to-proline mutation in the putative first transmembrane domain of the 22-kDa peripheral myelin protein in the trembler-J mouse.  |  Suter, U., et al. 1992. Proc Natl Acad Sci U S A. 89: 4382-6. PMID: 1374899
3. The gene encoding for the major brain proteolipid (PLP) maps on the q-22 band of the human X chromosome.  |  Mattei, MG., et al. 1986. Hum Genet. 72: 352-3. PMID: 3457761
4. Assignment of the gene for myelin proteolipid protein to the X chromosome: implications for X-linked myelin disorders.  |  Willard, HF. and Riordan, JR. 1985. Science. 230: 940-2. PMID: 3840606
5. Structure and chromosomal localization of the gene encoding the human myelin protein zero (MPZ).  |  Hayasaka, K., et al. 1993. Genomics. 17: 755-8. PMID: 7503936
6. Girl with signs of Pelizaeus-Merzbacher disease heterozygous for a mutation in exon 2 of the proteolipid protein gene.  |  Hodes, ME., et al. 1995. Am J Med Genet. 55: 397-401. PMID: 7539211