Plk Antibody (3F8): sc-53751
- Plk Antibody (3F8) is a mouse monoclonal IgG1, cited in 6 publications, provided at 50 µg/0.5 ml
- raised against amino acids 300-603 of Plk of human origin
- recommended for detection of Plk of mouse, rat and human origin by WB and IP
- See Plk (F-8): sc-17783 for Plk antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Plk Antibody (3F8). This work is in progress.
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SEE ALSO...
Plk Antibody (3F8) is a mouse monoclonal IgG1 antibody that detects Plk in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Plk, or polo-like kinase, is a crucial serine/threonine kinase that plays a significant role in cell cycle regulation, particularly during mitosis. Plk is essential for the proper functioning of the mitotic spindle, a structure that segregates chromosomes during cell division. Plk protein accumulates during the S and G2 phases of the cell cycle, with levels and catalytic activity peaking at the onset of mitosis, which is vital for ensuring accurate chromosome segregation and preventing aneuploidy. Following mitosis, Plk levels rapidly decline, highlighting a transient yet critical role in cell division. Notably, Plk expression is found in mitotically active tissues such as the colon and placenta, as well as in various tumors, suggesting potential as a biomarker for cell proliferation and a target for cancer therapies. Anti-Plk antibody (3F8) provides a reliable tool for researchers investigating the dynamics of cell division and the implications of Plk in cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Plk Antibody (3F8) | sc-53751 | 50 µg/0.5 ml | $322.00 |