PlGF Antibody (MM0010-2D93): sc-101572

PlGF Antibody (MM0010-2D93) is a mouse monoclonal IgG1 antibody that detects placenta growth factor (PlGF) in human samples through applications such as western blotting (WB) and immunofluorescence (IF). PlGF plays a crucial role in angiogenesis, particularly in tumorigenesis, where PlGF expression can significantly influence tumor progression and metastasis. PlGF (MM0010-2D93) antibody targets a protein primarily secreted by macrophages and found in various tissues, including the placenta, where PlGF is essential for vascular development. PlGF localization in the extracellular matrix and interaction with endothelial cells are vital for promoting blood vessel formation, which is key in both normal physiological conditions and pathological states such as cancer. PlGF can form homodimers and heterodimers with vascular endothelial growth factor (VEGF), enhancing angiogenic potential. PlGF activation of the Flt-1 receptor, along with Flk-1/KDR interaction, underscores importance in mediating angiogenic signaling pathways. Anti-PlGF antibody (MM0010-2D93) enables researchers to gain valuable insights into PlGF′s role in various biological processes and disease states, making this monoclonal antibody an essential tool for studying angiogenesis and cancer research implications.

The preferred PlGF antibody is PlGF Antibody (H-4): sc-518003.