PlGF Antibody (37203.111): sc-57402
- PlGF Antibody (37203.111) is a mouse monoclonal IgG1 PlGF antibody, cited in 1 publications, provided at 100 µg/ml
- raised against an internal region of PIGF of human origin
- recommended for detection of PlGF of human origin by WB and ELISA; non cross-reactive with recombinant human VEGF, PDGFAA, PDGFAB and PDGFBB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PlGF Antibody (37203.111). This work is in progress.
QUICK LINKS
SEE ALSO...
PlGF Antibody (37203.111) is a mouse monoclonal IgG1 antibody that detects human PlGF by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-PlGF antibody (37203.111) is available as a non-conjugated isotype antibody. Placental Growth Factor (PlGF) plays a crucial role in angiogenesis, which is the formation of new blood vessels, a process vital for normal development and wound healing. Aberrant angiogenesis is implicated in various pathological conditions, including cancer, where PlGF can facilitate tumor growth and metastasis. PlGF interacts with vascular endothelial growth factor receptor 1 (Flt-1) and can activate Flk-1/KDR, both key players in angiogenic signaling pathways. PlGF exists in several isoforms due to alternative splicing of mRNA, and physiological effects are closely linked to VEGF, with evidence suggesting many actions attributed to VEGF may involve PlGF signaling. PlGF promotes endothelial cell proliferation and migration, underscoring importance in both physiological and pathological angiogenesis, making PlGF a significant target for therapeutic interventions in diseases characterized by abnormal blood vessel formation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PlGF Antibody (37203.111) References:
- Tumor angiogenesis: the role of oncogenes and tumor suppressor genes. | Bouck, N. 1990. Cancer Cells. 2: 179-85. PMID: 1696827
- The vascular endothelial growth factor family of polypeptides. | Ferrara, N., et al. 1991. J Cell Biochem. 47: 211-8. PMID: 1791185
- Angiogenic factors. | Folkman, J. and Klagsbrun, M. 1987. Science. 235: 442-7. PMID: 2432664
- Induction of angiogenesis during the transition from hyperplasia to neoplasia. | Folkman, J., et al. 1989. Nature. 339: 58-61. PMID: 2469964
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PlGF Antibody (37203.111) | sc-57402 | 100 µg/ml | $316.00 |