plexin-B2 Antibody (A-5): sc-373969

plexin-B2 Antibody (A-5) is a mouse monoclonal IgM antibody that detects plexin-B2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-plexin-B2 antibody (A-5) is available as a non-conjugated format. plexin-B2 plays a crucial role in the nervous system, particularly in axon guidance and neuronal development, by serving as a receptor for semaphorin 4D (Sema4D). This interaction is vital for proper formation of neural circuits during embryonic development, as plexin-B2 stimulates axonal outgrowth in dorsal root ganglion neurons. Additionally, plexin-B2 is involved in various signaling pathways that influence cell migration and tissue patterning, making plexin-B2 an important target for research in neurobiology and developmental biology. Understanding plexin-B2 function and interactions with semaphorins can provide insights into mechanisms underlying neural development and potential therapeutic targets for neurodegenerative diseases.

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plexin-B2 Antibody (A-5) References:

1. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.  |  Takahashi, T., et al. 1999. Cell. 99: 59-69. PMID: 10520994
2. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.  |  Tamagnone, L., et al. 1999. Cell. 99: 71-80. PMID: 10520995
3. Plexins, semaphorins, and scatter factor receptors: a common root for cell guidance signals?  |  Artigiani, S., et al. 1999. IUBMB Life. 48: 477-82. PMID: 10637762
4. Plexin-B3 is a functional receptor for semaphorin 5A.  |  Artigiani, S., et al. 2004. EMBO Rep. 5: 710-4. PMID: 15218527
5. Sema4D stimulates axonal outgrowth of embryonic DRG sensory neurones.  |  Masuda, K., et al. 2004. Genes Cells. 9: 821-9. PMID: 15330859
6. Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin.  |  Yu, W., et al. 2017. Cell. 171: 849-864.e25. PMID: 29100074
7. Muscone Can Improve Spinal Cord Injury by Activating the Angiogenin/Plexin-B2 Axis.  |  Zhou, Y., et al. 2022. Mol Neurobiol. 59: 5891-5901. PMID: 35809154
8. Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis imperfecta, hearing loss and intellectual disability.  |  Smith, CEL., et al. 2024. J Med Genet. 61: 689-698. PMID: 38458752
9. The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules.  |  Kolodkin, AL., et al. 1993. Cell. 75: 1389-99. PMID: 8269517
10. Identification of plexin family molecules in mice.  |  Kameyama, T., et al. 1996. Biochem Biophys Res Commun. 226: 396-402. PMID: 8806646
11. Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors.  |  Tamagnone, L. and Comoglio, PM. 1997. Cytokine Growth Factor Rev. 8: 129-42. PMID: 9244408
12. Plexin A is a neuronal semaphorin receptor that controls axon guidance.  |  Winberg, ML., et al. 1998. Cell. 95: 903-16. PMID: 9875845

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-plexin-B2 Antibody (A-5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-plexin-B2 Antibody (A-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

plexin-B2 Antibody (A-5) Specifications

Alternate Product Name: plexin-B2

Product Clone Name: A-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1103-1136

Epitope Target: plexin-B2

Epitope Species: human

Product Reactivity/Detection: plexin-B2 precursor and mature

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for plexin-B2 Antibody (A-5): P: Blocking Peptide